Conditional M. tuberculosis knockdown mutants in mice with human-like pathology
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
Mouse models are critical for studying the pathogenesis of tuberculosis (TB) and for assessing new drug targets, treatment regimens and vaccine strategies. Standard C57BL/6 and BALB/c mouse models do not develop the pathology observed in humans, such as necrotic, hypoxic and caseating granulomas. In contrast C3HeB/FeJ mice develop a spectrum of TB lesions that more closely resemble human granulomas and other pathological environments. However, this mouse strain has rarely been utilized to investigate Mycobacterium tuberculosis (Mtb) mutants or paucibacillary Mtb infections that mimic latent infections in humans. We propose to analyze conditional knockdown mutants for thioredoxin reductase (TrxB2) and biotin protein ligase (BPL) in C3HeB/FeJ mice. We will determine the ability of conditional Mtb mutants to establish infection in mice with human-like pathological environments and determine the impact of TrxB2 and BPL depletion in different lesion types. We will establish genetic latency models in C3HeB/FeJ mice and test the hypothesis that a larger percentage of mice with caseous necrotic pulmonary granulomas will harbor latent bacilli that cause TB relapse than observed in C57BL/6 mice.
Grant Summary
Conditional M. tuberculosis knockdown mutants in mice with human-like pathology is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $212K for university, nonprofit, healthcare org. Applications are due 2028-01-31 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $212K
2028-01-31
- 1Confirm your organization is eligible for Conditional M. tuberculosis knockdown mutants in mice with human-like pathology from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Conditional M. tuberculosis knockdown mutants in mice with human-like pathology: Frequently Asked Questions
Who is eligible for the Conditional M. tuberculosis knockdown mutants in mice with human-like pathology?
Conditional M. tuberculosis knockdown mutants in mice with human-like pathology is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Conditional M. tuberculosis knockdown mutants in mice with human-like pathology provide?
Conditional M. tuberculosis knockdown mutants in mice with human-like pathology provides up to $212K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Conditional M. tuberculosis knockdown mutants in mice with human-like pathology deadline?
Applications for Conditional M. tuberculosis knockdown mutants in mice with human-like pathology are due 2028-01-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Conditional M. tuberculosis knockdown mutants in mice with human-like pathology?
To apply for Conditional M. tuberculosis knockdown mutants in mice with human-like pathology, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.