Non-siderophore function of peroxisomes in Histoplasma pathogenesis
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
PROJECT SUMMARY The fungal pathogen Histoplasma capsulatum infects and thrives within phagocytes of the immune system. Results from a genetic screen indicate that peroxisome organelles play a critical role in facilitating Histoplasma proliferation in macrophages. Preliminary work demonstrated that the known peroxisomal functions of fatty acid β-oxidation, the glyoxylate cycle, and catalase destruction of reactive oxygen are all dispensible for Histoplasma pathogenesis indicating that peroxisomes play a novel role. This proposal will uncover new peroxisome functions by definition of the peroxisome proteome and metabolome in pathogenic-phase fungal cells. Candidate peroxisomal functions will be validated by functional tests to determine their contributions to Histoplasma’s intramacrophage proliferation. This work will uncover new peroxisomal functions and reveal novel mechanisms for fungal exploitation of the macrophage.
Grant Summary
Non-siderophore function of peroxisomes in Histoplasma pathogenesis is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $354K for university, nonprofit, healthcare org. Applications are due 2028-01-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $354K
2028-01-31
- 1Confirm your organization is eligible for Non-siderophore function of peroxisomes in Histoplasma pathogenesis from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Non-siderophore function of peroxisomes in Histoplasma pathogenesis: Frequently Asked Questions
Who is eligible for the Non-siderophore function of peroxisomes in Histoplasma pathogenesis?
Non-siderophore function of peroxisomes in Histoplasma pathogenesis is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Non-siderophore function of peroxisomes in Histoplasma pathogenesis provide?
Non-siderophore function of peroxisomes in Histoplasma pathogenesis provides up to $354K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Non-siderophore function of peroxisomes in Histoplasma pathogenesis deadline?
Applications for Non-siderophore function of peroxisomes in Histoplasma pathogenesis are due 2028-01-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Non-siderophore function of peroxisomes in Histoplasma pathogenesis?
To apply for Non-siderophore function of peroxisomes in Histoplasma pathogenesis, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.