Deciphering Virulence Determinants of Human-Pathogenic Atypical Toxoplasma gondii
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
1 PROJECT SUMMARY 2 3 Apicomplexan parasites are a major cause of mortality and morbidity in humans and animals. As a 4 model apicomplexan parasite, Toxoplasma gondii is highlighted by the CDC as the 2nd leading cause of 5 foodborne illness in the US and is classified as an NIAID Emerging/Re-emerging Pathogen. While life- 6 threatening diseases can occur in immunocompromised individuals and fetuses, infections caused by clonal 7 strains frequently found in Europe and North America are mostly benign in healthy humans. However, severe 8 toxoplasmosis outbreaks with fatal consequences among healthy individuals have been documented in South 9 America, where a variety of non-clonal genetically heterogeneous Toxoplasma strains with distinct virulent 10 features are prevalent. To date, the virulence characteristics and parasite genes responsible for the 11 pathogenicity of such Toxoplasma strains in humans remain largely unknown. 12 This project focuses on the virulence traits of human-pathogenic, atypical Toxoplasma strains in the 13 laboratory rat model and aims to understand the genomic basis of pathogenicity and identify genes 14 determining the parasite virulence. The proposal is organized into two specific aims: 1) to elucidate the 15 pathogenic potential of these atypical Toxoplasma strains in the rat model in vivo enabling downstream 16 phylogenetic analysis of known virulence factor and facilitating comparastive genome analysis to detect 17 additional virulence determinants; 2) to utilize a CRISPR/Cas9-based functional genomic screening approach, 18 both in vivo and in vitro, to uncover novel virulence factors in one atypical Toxoplasma strain associated with 19 human fatality. Collectively, the completion of this project will provide novel insight into the molecular basis of 20 high-pathogenic Toxoplasma outbreaks in the human population and contribute to building the scientific 21 framework for the development of therapeutic strategies against acute toxoplasmosis.
Grant Summary
Deciphering Virulence Determinants of Human-Pathogenic Atypical Toxoplasma gondii is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $412K for university, nonprofit, healthcare org. Applications are due 2028-01-31 (open). Check eligibility and apply with FindGrants.
Not quite the right fit?
Search 9,000+ open grants, or get matches ranked for your organization — free.
Focus Areas
Eligibility
How to Apply
Up to $412K
2028-01-31
- 1Confirm your organization is eligible for Deciphering Virulence Determinants of Human-Pathogenic Atypical Toxoplasma gondii from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
Don't want to draft it yourself?
We'll draft the complete application against NIAID - National Institute of Allergy and Infectious Diseases's requirements, run a quality review, and email you a submission-ready PDF plus an editable Word doc within 5 business days. Most orders deliver in 24-48 hours. Flat $399, any grant size.
AI Requirement Analysis
Detailed requirements not yet analyzed
Have the NOFO? Paste it below for AI-powered requirement analysis.
Deciphering Virulence Determinants of Human-Pathogenic Atypical Toxoplasma gondii: Frequently Asked Questions
Who is eligible for the Deciphering Virulence Determinants of Human-Pathogenic Atypical Toxoplasma gondii?
Deciphering Virulence Determinants of Human-Pathogenic Atypical Toxoplasma gondii is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Deciphering Virulence Determinants of Human-Pathogenic Atypical Toxoplasma gondii provide?
Deciphering Virulence Determinants of Human-Pathogenic Atypical Toxoplasma gondii provides up to $412K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Deciphering Virulence Determinants of Human-Pathogenic Atypical Toxoplasma gondii deadline?
Applications for Deciphering Virulence Determinants of Human-Pathogenic Atypical Toxoplasma gondii are due 2028-01-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Deciphering Virulence Determinants of Human-Pathogenic Atypical Toxoplasma gondii?
To apply for Deciphering Virulence Determinants of Human-Pathogenic Atypical Toxoplasma gondii, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.