Decoding the Muscle Epitranscriptome: Deep Learning Detection of RNA Modifications in Aging Muscle
About This Grant
ABSTRACT RNA modifications represent a critical but poorly understood mechanism regulating protein production in aging muscle tissue. This proposal develops innovative computational and experimental approaches to map and understand how chemical modifications of RNA molecules change during muscle aging. Using a combination of cutting-edge nanopore sequencing technology and artificial intelligence, we will create new methods to precisely detect RNA modifications, particularly 5-methylcytosine (m5C), in muscle tissue. We will then apply these methods to examine how modification patterns differ between fast- and slow-twitch muscle fibers across age and sex, while determining their impact on protein synthesis. The project introduces novel synthetic RNA training strategies for improved modification detection while integrating chemical biology, machine learning, and muscle physiology. This work will establish new paradigms for studying RNA modifications in aging tissues while revealing fundamental mechanisms of muscle aging. The findings will identify potential RNA-based therapeutic targets for age-related muscle loss while providing valuable resources for the broader aging research community.
Grant Summary
Decoding the Muscle Epitranscriptome: Deep Learning Detection of RNA Modifications in Aging Muscle is a NIA - National Institute on Aging grant providing up to $616K for university, nonprofit, healthcare org. Applications are due 2029-01-31 (open). Check eligibility and apply with FindGrants.
Not quite the right fit?
Search 9,000+ open grants, or get matches ranked for your organization — free.
Focus Areas
Eligibility
How to Apply
Up to $616K
2029-01-31
- 1Confirm your organization is eligible for Decoding the Muscle Epitranscriptome: Deep Learning Detection of RNA Modifications in Aging Muscle from NIA - National Institute on Aging, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIA - National Institute on Aging before the deadline.
Don't want to draft it yourself?
We'll draft the complete application against NIA - National Institute on Aging's requirements, run a quality review, and email you a submission-ready PDF plus an editable Word doc within 5 business days. Most orders deliver in 24-48 hours. Flat $399, any grant size.
AI Requirement Analysis
Detailed requirements not yet analyzed
Have the NOFO? Paste it below for AI-powered requirement analysis.
Decoding the Muscle Epitranscriptome: Deep Learning Detection of RNA Modifications in Aging Muscle: Frequently Asked Questions
Who is eligible for the Decoding the Muscle Epitranscriptome: Deep Learning Detection of RNA Modifications in Aging Muscle?
Decoding the Muscle Epitranscriptome: Deep Learning Detection of RNA Modifications in Aging Muscle is offered by NIA - National Institute on Aging and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Decoding the Muscle Epitranscriptome: Deep Learning Detection of RNA Modifications in Aging Muscle provide?
Decoding the Muscle Epitranscriptome: Deep Learning Detection of RNA Modifications in Aging Muscle provides up to $616K per award from NIA - National Institute on Aging. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Decoding the Muscle Epitranscriptome: Deep Learning Detection of RNA Modifications in Aging Muscle deadline?
Applications for Decoding the Muscle Epitranscriptome: Deep Learning Detection of RNA Modifications in Aging Muscle are due 2029-01-31 (open). Because deadlines can change, verify the date with the funder, NIA - National Institute on Aging, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Decoding the Muscle Epitranscriptome: Deep Learning Detection of RNA Modifications in Aging Muscle?
To apply for Decoding the Muscle Epitranscriptome: Deep Learning Detection of RNA Modifications in Aging Muscle, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIA - National Institute on Aging.