Assessing the tolerability and versatility of the new Spytag003/Spycatcher003 as a novel bio-conjugation system for displaying protein antigens on the surface of bacteriophage VLPs
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
PROJECT SUMMARY Peptide and protein antigen vaccines are very safe compared to live-attenuated vaccines. They can be used to immunize anyone and are not associated with a lot of side effects compared to live-attenuated vaccines. However, peptides and proteins are less immunogenic compared to live-attenuated vaccines. To overcome these limitations, peptide antigens have been inserted/displayed on the surface of virus-like particles (VLPs) to increase their size as well as the valency or density of the peptide. VLPs are morphologically and structurally similar to viruses from which the coat proteins are derived from, except for the fact that they lack the viral genome. VLPs are highly immunogenic even at small doses of antigens. Most peptide antigens can be displayed on VLPs by genetic insertion or by chemical conjugation (to make them multivalent and highly immunogenic). However, these two approaches cannot be used for every peptide not to mention protein antigens. The size of an antigen as well as the composition of the antigen most of the time interferes with these two conjugation approaches. These limitations make in very impossible to use identified antigens with neutralizing and protective epitopes in vaccine design. To overcome the limitations with genetic and chemical conjugation approaches, we propose to explore a novel bio-conjugation approach on 4 bacteriophage VLPs (MS2, PP7, AP205, Q). This approach will use the new Spytag003/Spycatcher003 bio-conjugation system developed from the prototype Spytag/Spycatcher. In the proposed study, we will assess the potential of using the new Spytag003/Spycatcher003 bio-conjugation system to display diverse protein antigens on the surface of 4 bacteriophage VLPs. We will assess the versatility of the new bio-conjugation system on these VLPs using diverse protein antigens that differ in origin, size, and conformation.
Grant Summary
Assessing the tolerability and versatility of the new Spytag003/Spycatcher003 as a novel bio-conjugation system for displaying protein antigens on the surface of bacteriophage VLPs is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $588K for university, nonprofit, healthcare org. Applications are due 2029-03-31 (open). Check eligibility and apply with FindGrants.
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Up to $588K
2029-03-31
- 1Confirm your organization is eligible for Assessing the tolerability and versatility of the new Spytag003/Spycatcher003 as a novel bio-conjugation system for displaying protein antigens on the surface of bacteriophage VLPs from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
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Assessing the tolerability and versatility of the new Spytag003/Spycatcher003 as a novel bio-conjugation system for displaying protein antigens on the surface of bacteriophage VLPs: Frequently Asked Questions
Who is eligible for the Assessing the tolerability and versatility of the new Spytag003/Spycatcher003 as a novel bio-conjugation system for displaying protein antigens on the surface of bacteriophage VLPs?
Assessing the tolerability and versatility of the new Spytag003/Spycatcher003 as a novel bio-conjugation system for displaying protein antigens on the surface of bacteriophage VLPs is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Assessing the tolerability and versatility of the new Spytag003/Spycatcher003 as a novel bio-conjugation system for displaying protein antigens on the surface of bacteriophage VLPs provide?
Assessing the tolerability and versatility of the new Spytag003/Spycatcher003 as a novel bio-conjugation system for displaying protein antigens on the surface of bacteriophage VLPs provides up to $588K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Assessing the tolerability and versatility of the new Spytag003/Spycatcher003 as a novel bio-conjugation system for displaying protein antigens on the surface of bacteriophage VLPs deadline?
Applications for Assessing the tolerability and versatility of the new Spytag003/Spycatcher003 as a novel bio-conjugation system for displaying protein antigens on the surface of bacteriophage VLPs are due 2029-03-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Assessing the tolerability and versatility of the new Spytag003/Spycatcher003 as a novel bio-conjugation system for displaying protein antigens on the surface of bacteriophage VLPs?
To apply for Assessing the tolerability and versatility of the new Spytag003/Spycatcher003 as a novel bio-conjugation system for displaying protein antigens on the surface of bacteriophage VLPs, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.