Cardiometabolism in Health and Disease

About This Grant

Abstract Support is requested for a Keystone Symposia conference entitled “Cardiometabolism in Health and Disease,” organized by Drs. Daniel P. Kelly, Rong Tian and William C. Sessa, with scientific programming input from Keystone Symposia. The meeting will take place January 26–29, 2026 at the Keystone Resort in Keystone, Colorado. There has been a groundbreaking surge in knowledge regarding the intertwined health challenges of obesity and cardiovascular disease. Cardiovascular outcomes in recent trials have unveiled an extraordinary, though not fully understood, cardioprotective effect of diabetes and obesity medications. Concurrently, innovative technologies now enable comprehensive real-time analysis of systemic, organ, and cellular metabolism under these treatment regimes. This Keystone Symposia meeting will delve into critical topics in cardiometabolism in both health and disease, including the metabolic foundations of heart and vascular health/disease; the interplay between organs that underpins the synergy among obesity, insulin resistance, and cardiovascular disease; the mechanisms by which new drugs, such as SGLT2 inhibitors and GLP-1 receptor agonists, mitigate cardiovascular events; and the influence of environmental factors, such as diet and circadian rhythms, on cardiovascular health and disease. Conference sessions will highlight presentations from global experts and encourage interactive discussions relevant to the understanding and treatment of the growing unmet health problem of heart and vascular disease in the growing population of patients with obesity and diabetes. Additionally, this conference has been paired with another Keystone Symposia conference, “Obesity Therapeutics: Unlocking Benefits and Minimizing Side Effects,” and will present groundbreaking research from both basic and translational science on the treatment of obesity and cardiometabolic disease. In this regard, this pairing provides greater opportunities for cross-fertilization of ideas and the initiation of novel research directions and collaborations among a multidisciplinary group of leading researchers.