Reimagining Diabetes: From Molecular Mechanisms to Transformative Therapies

About This Grant

Abstract Support is requested for a Keystone Symposia conference entitled Reimagining Diabetes: From Molecular Mechanisms to Transformative Therapies, organized by Drs. Anna Krook, Jennifer Green and David Moller, with scientific programming input from Keystone Symposia. The meeting will take place January 31–February 04, 2027, at Keystone Resort in Keystone, Colorado. Despite breakthrough medicines, the burden of diabetes and comorbid conditions – including obesity, cardio- renal disease and others – continues to rise at an alarming rate. This meeting on Reimagining Diabetes: From Molecular Mechanisms to Transformative Therapies, planned in collaboration with the Endocrine Society, will explore gaps and challenges in our understanding of pathobiology of diabetes and define emerging therapeutic approaches that hold promises for addressing unmet clinical needs and reversing the trajectory of disease progression. The primary goals of the Keystone Symposia–Endocrine Society conference series are to integrate ‘bench-to-bedside-and-back’ perspectives and to increase crosstalk among basic, translational and clinical researchers across endocrine and metabolic-related areas, with the intent of spurring innovative basic research informed by real-time clinical insights that will, in turn, create new therapeutic hypotheses, accelerate future clinical development and enhance treatment outcomes across disease areas. This specific conference aims to share knowledge, spark scientific collaboration, and generate new research and development ideas. It will focus on three themes: (1) basic science, including genetic research into disease causation; (2) novel therapeutic targets and strategies, emphasizing non-incretin and disease-modifying approaches; and (3) innovative research and clinical tools for enhancing therapeutic impact. The meeting will bring together established and early-career researchers from diverse fields who infrequently collaborate, creating a unique platform for interaction among academic researchers, industry scientists, and clinical investigators. Beyond the scientific talks, the conference will include interactive workshops and panels focusing on lessons from clinical trials, broader discussion of improving health outcomes and an emphasis on career development of early-career scientists.