Early Immune Signatures of COPD: Linking Inflammation to Disease Progression
About This Grant
PROJECT SUMMARY/ABSTRACT The R03 application builds upon Dr. Yun’s K08-funded study, which investigated how hedgehog interacting protein (HHIP) deficiency contributes to lymphocytic inflammation in chronic obstructive pulmonary disease (COPD). Through that work, we identified unique CD8+T cell populations in both a murine model and human COPD lungs. In this proposal we will focus on a specific CD8+T cell subset expanded in mild to moderate (early) COPD and investigate its contribution to COPD development and progression. By leveraging longitudinal cohorts and single-cell immune profiling, we will determine 1) whether this subset is associated with COPD development and progression, and 2) the clonal and antigenic drivers that underlying its expansion. Our emphasis on defining the transcriptomic, clonal, and antigenic properties of this CD8+T cell subset in COPD will advance our understanding of inflammatory pathogenesis and potentially provide a foundation for novel therapeutic strategies aimed at slowing disease progression.
Grant Summary
Early Immune Signatures of COPD: Linking Inflammation to Disease Progression is a NHLBI - National Heart Lung and Blood Institute grant providing up to $121K for university, nonprofit, healthcare org. Applications are due 2027-12-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $121K
2027-12-31
- 1Confirm your organization is eligible for Early Immune Signatures of COPD: Linking Inflammation to Disease Progression from NHLBI - National Heart Lung and Blood Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NHLBI - National Heart Lung and Blood Institute before the deadline.
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Early Immune Signatures of COPD: Linking Inflammation to Disease Progression: Frequently Asked Questions
Who is eligible for the Early Immune Signatures of COPD: Linking Inflammation to Disease Progression?
Early Immune Signatures of COPD: Linking Inflammation to Disease Progression is offered by NHLBI - National Heart Lung and Blood Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Early Immune Signatures of COPD: Linking Inflammation to Disease Progression provide?
Early Immune Signatures of COPD: Linking Inflammation to Disease Progression provides up to $121K per award from NHLBI - National Heart Lung and Blood Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Early Immune Signatures of COPD: Linking Inflammation to Disease Progression deadline?
Applications for Early Immune Signatures of COPD: Linking Inflammation to Disease Progression are due 2027-12-31 (open). Because deadlines can change, verify the date with the funder, NHLBI - National Heart Lung and Blood Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Early Immune Signatures of COPD: Linking Inflammation to Disease Progression?
To apply for Early Immune Signatures of COPD: Linking Inflammation to Disease Progression, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NHLBI - National Heart Lung and Blood Institute.