Dynamic Imaging with Sparse Total-Body Positron Emission Tomography
NIBIB - National Institute of Biomedical Imaging and Bioengineering
About This Grant
Abstract Total-body (TB) Positron Emission Tomography (PET) is a medical imaging technology that enables comprehensive imaging of metabolic processes across the entire body in a single bed position. It offers substantial advantages for dynamic imaging and kinetic modeling, such as high temporal resolution and multiparametric capabilities, making it invaluable for assessing cancer staging, early treatment response, and distinguishing malignancy from infection/inflammation. However, the widespread adoption of TB PET is limited by its high cost, primarily due to the expense of scintillator material and readout electronics. This proposal seeks to develop an affordable dynamic TB PET system through the use of sparse detector architectures, which will reduce material costs while maintaining the performance benefits of full-body coverage. We hypothesize that sparse designs can produce high-quality dynamic images that allow for kinetic modeling and parametric imaging with minimal loss of quantitative accuracy compared to full-rank TB PET. Our innovative approach combines spatial down sampling of the detector matrix of the 2-m long EXPLORER TB PET scanner with advanced reconstruction algorithms. Classical and deep learning-based Kernel methods will help recover image quality in high-noise, low-count environments. This project will address three specific aims: (1) demonstrating parametric imaging using sparse TB PET, (2) comparing image quality between sparse TB PET and conventional PET scanners, and (3) optimizing reconstruction parameters and detector matrix configurations for high temporal resolution in dynamic imaging. By achieving these aims, we will develop a robust, cost- effective TB PET system with potential to revolutionize both clinical and research applications. The successful implementation of this technology will expand access to dynamic TB PET, enhance diagnostic workflows, and accelerate research in cancer and other diseases.
Grant Summary
Dynamic Imaging with Sparse Total-Body Positron Emission Tomography is a NIBIB - National Institute of Biomedical Imaging and Bioengineering grant providing up to $161K for university, nonprofit, healthcare org. Applications are due 2028-04-30 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $161K
2028-04-30
- 1Confirm your organization is eligible for Dynamic Imaging with Sparse Total-Body Positron Emission Tomography from NIBIB - National Institute of Biomedical Imaging and Bioengineering, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIBIB - National Institute of Biomedical Imaging and Bioengineering before the deadline.
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Dynamic Imaging with Sparse Total-Body Positron Emission Tomography: Frequently Asked Questions
Who is eligible for the Dynamic Imaging with Sparse Total-Body Positron Emission Tomography?
Dynamic Imaging with Sparse Total-Body Positron Emission Tomography is offered by NIBIB - National Institute of Biomedical Imaging and Bioengineering and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Dynamic Imaging with Sparse Total-Body Positron Emission Tomography provide?
Dynamic Imaging with Sparse Total-Body Positron Emission Tomography provides up to $161K per award from NIBIB - National Institute of Biomedical Imaging and Bioengineering. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Dynamic Imaging with Sparse Total-Body Positron Emission Tomography deadline?
Applications for Dynamic Imaging with Sparse Total-Body Positron Emission Tomography are due 2028-04-30 (open). Because deadlines can change, verify the date with the funder, NIBIB - National Institute of Biomedical Imaging and Bioengineering, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Dynamic Imaging with Sparse Total-Body Positron Emission Tomography?
To apply for Dynamic Imaging with Sparse Total-Body Positron Emission Tomography, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIBIB - National Institute of Biomedical Imaging and Bioengineering.