Manipulating PIWI-interacting RNA to generate sterile ticks
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
SUMMARY The Piwi-interacting RNA (piRNA) pathway is a conserved genome surveillance mechanism essential for germline integrity and fertility in invertebrates, including ticks. Piwi (P-element Induced Wimpy Testis) proteins play a critical role in silencing transposable elements (TEs) to preserve genome stability in germ cells. Our preliminary data shows that depletion of Piwi transcript in ticks leads to reproductive failure, establishing a novel target for developing sterile insect technology (SIT) against ticks. The overall goal of this application is to develop a mechanistic framework for piRNA-based SIT by manipulating the tick piRNA pathway and evaluating its impact on fertility and pathogen transmission. Our central hypothesis is that disrupting the piRNA pathway in ticks will induce sterility by derepressing transposable elements, impairing germline genome integrity, and ultimately reducing vector fitness. To test this hypothesis, we propose a single aim to disrupt the piRNA pathway in ticks to induce sterility and reduce vector competence. This study will define a Piwi knockdown signature characterized by TE derepression and sterility. These experimental findings will establish a rational foundation for the development of a piRNA-based SIT platform targeting tick vectors. Moreover, the outcome of this project could be extended to other tick species of public health significance.
Grant Summary
Manipulating PIWI-interacting RNA to generate sterile ticks is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $150K for university, nonprofit, healthcare org. Applications are due 2028-05-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $150K
2028-05-31
- 1Confirm your organization is eligible for Manipulating PIWI-interacting RNA to generate sterile ticks from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Manipulating PIWI-interacting RNA to generate sterile ticks: Frequently Asked Questions
Who is eligible for the Manipulating PIWI-interacting RNA to generate sterile ticks?
Manipulating PIWI-interacting RNA to generate sterile ticks is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Manipulating PIWI-interacting RNA to generate sterile ticks provide?
Manipulating PIWI-interacting RNA to generate sterile ticks provides up to $150K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Manipulating PIWI-interacting RNA to generate sterile ticks deadline?
Applications for Manipulating PIWI-interacting RNA to generate sterile ticks are due 2028-05-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Manipulating PIWI-interacting RNA to generate sterile ticks?
To apply for Manipulating PIWI-interacting RNA to generate sterile ticks, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.