Dissecting the intrinsic role of SLC4A2 in the development of liver inflammation in a mouse model of PBC
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
Project Summary/Abstract The SLC4A2 (or Anion Exchanger2, AE2) is a ubiquitous membrane transporter that mediates the sodium (Na+)- independent and electroneutral exchange of chloride (Cl−) and bicarbonate (HCO3−) ions, and participates in the regulation of intracellular pH (pHi). AE2-deficiency in humans has been linked with the development of Primary Biliary Cholangitis (PBC), which is a chronic cholestatic liver disease associated with autoimmune phenomena. Supporting these findings, mice with whole-body deletion of SLC4A2 develop a spontaneous and progressive autoimmune cholangitis that resembles the human PBC. However, the cell intrinsic requirement of SLC4A2 in immune cells and/or biliary epithelial cells and the mechanisms underlying the loss of tolerance against biliary epithelial cells in the absence of SLC4A2 are unknown. Here, we aim to dissect the role of SLC4A2 in the development of liver inflammation and autoimmune cholangitis using SLC4A2 conditional knockout (cKO) mice. To this end, we have generated tissue-specific SLC4A2-cKO in the liver (i.e., Slc4a2fl/flAlbCre+ mice) as well as in T cells (i.e., Slc4a2fl/flCd4Cre+ mice) to study the requirement of this membrane transporter in immune tolerance in the liver. We aim to: 1) characterize the immune cell composition in the liver and lymphoid organs of Slc4a2fl/flCd4Cre+, Slc4a2fl/flAlbCre+ mice and their control littermates, and ii) study the alterations that occur in T cells and liver cells in the absence of SLC4A2. Investigating the mechanisms underlying the autoimmune cholangitis and liver inflammation caused by SLC4A2 deficiency in mice will be an important step forward to better understand the etiopathogenesis of PBC and to the development of future therapeutic approaches to treat these patients.
Grant Summary
Dissecting the intrinsic role of SLC4A2 in the development of liver inflammation in a mouse model of PBC is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $164K for university, nonprofit, healthcare org. Applications are due 2027-03-31 (open). Check eligibility and apply with FindGrants.
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Up to $164K
2027-03-31
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- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
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Dissecting the intrinsic role of SLC4A2 in the development of liver inflammation in a mouse model of PBC: Frequently Asked Questions
Who is eligible for the Dissecting the intrinsic role of SLC4A2 in the development of liver inflammation in a mouse model of PBC?
Dissecting the intrinsic role of SLC4A2 in the development of liver inflammation in a mouse model of PBC is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Dissecting the intrinsic role of SLC4A2 in the development of liver inflammation in a mouse model of PBC provide?
Dissecting the intrinsic role of SLC4A2 in the development of liver inflammation in a mouse model of PBC provides up to $164K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Dissecting the intrinsic role of SLC4A2 in the development of liver inflammation in a mouse model of PBC deadline?
Applications for Dissecting the intrinsic role of SLC4A2 in the development of liver inflammation in a mouse model of PBC are due 2027-03-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Dissecting the intrinsic role of SLC4A2 in the development of liver inflammation in a mouse model of PBC?
To apply for Dissecting the intrinsic role of SLC4A2 in the development of liver inflammation in a mouse model of PBC, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.