Immune evasive mouse models for transplantation research
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
Abstract: Decades of research on transplantation have made it clear that the immunological barriers to engraftment are substantial. The goal of this proposal is to generate transgenic mouse models that will allow standardized and orthogonal testing of pathways important for overcoming transplantation barriers, and through this work, instruct efforts in regenerative medicine. We will generate mice that, upon Cre recombinase expression, will express modules of genes that either 1) suppress complement deposition and membrane attack complex formation; 2) express single chain peptide-β2m-MHC trimers to engage inhibitory receptors on natural killer cells; 3) express CD47 to engage the inhibitory receptor Sirpα. These animals can be used as donors for future transplantation experiments to genetically define allogeneic barriers and instruct similar edits in stem cells for regenerative medicine.
Grant Summary
Immune evasive mouse models for transplantation research is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $155K for university, nonprofit, healthcare org. Applications are due 2028-05-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $155K
2028-05-31
- 1Confirm your organization is eligible for Immune evasive mouse models for transplantation research from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Immune evasive mouse models for transplantation research: Frequently Asked Questions
Who is eligible for the Immune evasive mouse models for transplantation research?
Immune evasive mouse models for transplantation research is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Immune evasive mouse models for transplantation research provide?
Immune evasive mouse models for transplantation research provides up to $155K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Immune evasive mouse models for transplantation research deadline?
Applications for Immune evasive mouse models for transplantation research are due 2028-05-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Immune evasive mouse models for transplantation research?
To apply for Immune evasive mouse models for transplantation research, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.