Development of An Integrated Pipeline for Early PD Prediction and Disease Modifying Drug Repurposing
NINDS - National Institute of Neurological Disorders and Stroke
About This Grant
ABSTRACT Parkinson's Disease (PD) is the second most prevalent neurodegenerative disorder all over the world. It is estimated that PD affects 2-3% of people older than 65 years. PD is associated with serious dysfunctions with movement, speech, swallowing, and balance, as well as non-motor symptoms like depression, anxiety, sleep, and cognitive problems, significantly impacting daily activities and ultimately affecting the ability to live independently and maintain a good quality of life. As of now, PD remains pathologically and biologically unclear; and no disease-modifying treatment (DMT) current exist that can slow, halt, or reverse PD disease course. Prior neuropathological evidence indicates that PD pathology may begin up to two decades prior to clinical presentation–40–60% of dopaminergic neurons in the substantia nigra have been lost at time of motor symptom manifesting. Therefore, by the time PD is clinically diagnosed, neurodegeneration may be too advanced to be modified by therapeutic intervention. This has been recognized as a potential reason for the failure of many DMT trials. The pre-diagnostic or prodromal phases of PD (pPD) might represent a critical therapeutic window, during which molecular pathology may still be reversible or more responsive to intervention. In this context, this project aims at targeting the pPD phase to advance development of DMTs for early PD prevention. To this end, Aim 1 will develop an advanced AI-driven framework for harmonizing multimodal health data across PD research datasets, general-purpose biomedical databases, and large-scale EHR, and for building multimodal AI model for early prediction of PD. Aim 2 will develop causal learning-based trial emulation framework to identify and evaluate DMT repurposing candidates in PD, targeting the population with pPD. Aim 3 will leverage PD-derived iPSCs (in vitro) and mouse models (in vivo) for screening and validating the drug repurposing candidates.
Grant Summary
Development of An Integrated Pipeline for Early PD Prediction and Disease Modifying Drug Repurposing is a NINDS - National Institute of Neurological Disorders and Stroke grant providing up to $671K for university, nonprofit, healthcare org. Applications are due 2031-04-30 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $671K
2031-04-30
- 1Confirm your organization is eligible for Development of An Integrated Pipeline for Early PD Prediction and Disease Modifying Drug Repurposing from NINDS - National Institute of Neurological Disorders and Stroke, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NINDS - National Institute of Neurological Disorders and Stroke before the deadline.
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Development of An Integrated Pipeline for Early PD Prediction and Disease Modifying Drug Repurposing: Frequently Asked Questions
Who is eligible for the Development of An Integrated Pipeline for Early PD Prediction and Disease Modifying Drug Repurposing?
Development of An Integrated Pipeline for Early PD Prediction and Disease Modifying Drug Repurposing is offered by NINDS - National Institute of Neurological Disorders and Stroke and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Development of An Integrated Pipeline for Early PD Prediction and Disease Modifying Drug Repurposing provide?
Development of An Integrated Pipeline for Early PD Prediction and Disease Modifying Drug Repurposing provides up to $671K per award from NINDS - National Institute of Neurological Disorders and Stroke. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Development of An Integrated Pipeline for Early PD Prediction and Disease Modifying Drug Repurposing deadline?
Applications for Development of An Integrated Pipeline for Early PD Prediction and Disease Modifying Drug Repurposing are due 2031-04-30 (open). Because deadlines can change, verify the date with the funder, NINDS - National Institute of Neurological Disorders and Stroke, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Development of An Integrated Pipeline for Early PD Prediction and Disease Modifying Drug Repurposing?
To apply for Development of An Integrated Pipeline for Early PD Prediction and Disease Modifying Drug Repurposing, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NINDS - National Institute of Neurological Disorders and Stroke.