The impact of sleep pressure and timing on hippocampal reactivation and replay
NINDS - National Institute of Neurological Disorders and Stroke
About This Grant
Abstract/Project Summary The circadian rhythm has strong effects on cognition and memory. There is also strong evidence that the activities of neurons during sleep are important for the memory function of the brain. Until recently, little was known about why delaying these activities for a prolonged period of wakefulness (commonly known as “sleep loss”) should have an enduring negative impact on memory, especially given the brain’s general capacity to restore itself during an eventual “recovery sleep”. Recently, by recording from large populations of hippocampal neurons in behaving and sleeping rodents, we found that the reactivation and replay of neuronal ensembles in the hippocampus during sharp-wave ripple events were significantly diminished during recovery sleep compared to in sleep immediately following behavior on a maze, suggesting that prolonged waking during the inactive cycle, when animals normally sleep, impairs the capacity of the hippocampus to generate the patterns widely considered most important for the consolidation of memories. However, key questions remain concerning how these sleep-dependent effects interact with the circadian cycle—known to impact learning and memory—and the optimal times and durations for waking and sleep for reactivations and replays that are critical to hippocampal function. In this proposal, we investigate how different periods of extended waking, at different phases of the circadian cycle, plus arousal enhanced by caffeine, impact hippocampal neuronal firing patterns during sharp-wave ripples, in both the awake state and the subsequent sleep. We further investigate the impact of enhancing these events by optogenetically prolonging their duration to test their impact on hippocampus-dependent memory. In sum, this work will help elucidate how sleep pressure and circadian timing interact to impact on hippocampal function and influence the systems-level firing patterns that are considered to support the hippocampal role in memory.
Grant Summary
The impact of sleep pressure and timing on hippocampal reactivation and replay is a NINDS - National Institute of Neurological Disorders and Stroke grant providing up to $532K for university, nonprofit, healthcare org. Applications are due 2031-03-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $532K
2031-03-31
- 1Confirm your organization is eligible for The impact of sleep pressure and timing on hippocampal reactivation and replay from NINDS - National Institute of Neurological Disorders and Stroke, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NINDS - National Institute of Neurological Disorders and Stroke before the deadline.
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The impact of sleep pressure and timing on hippocampal reactivation and replay: Frequently Asked Questions
Who is eligible for the The impact of sleep pressure and timing on hippocampal reactivation and replay?
The impact of sleep pressure and timing on hippocampal reactivation and replay is offered by NINDS - National Institute of Neurological Disorders and Stroke and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the The impact of sleep pressure and timing on hippocampal reactivation and replay provide?
The impact of sleep pressure and timing on hippocampal reactivation and replay provides up to $532K per award from NINDS - National Institute of Neurological Disorders and Stroke. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the The impact of sleep pressure and timing on hippocampal reactivation and replay deadline?
Applications for The impact of sleep pressure and timing on hippocampal reactivation and replay are due 2031-03-31 (open). Because deadlines can change, verify the date with the funder, NINDS - National Institute of Neurological Disorders and Stroke, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the The impact of sleep pressure and timing on hippocampal reactivation and replay?
To apply for The impact of sleep pressure and timing on hippocampal reactivation and replay, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NINDS - National Institute of Neurological Disorders and Stroke.