Neuronal Kinase Signaling in Health and Disease
NINDS - National Institute of Neurological Disorders and Stroke
About This Grant
ABSTRACT Kinase signaling plays a pivotal role in regulating neuronal physiology, yet the mechanisms underlying kinase specificity, subcellular compartmentalization, and disease-associated dysfunction remain poorly understood. Dysregulated kinase activity is a key driver of neurodegenerative disorders, including Parkinson’s Disease (PD), where mutations such as LRRK2G2019S alter kinase function and neuronal survival. This project leverages innovative AI/ML algorithms, advanced CRISPR-based proteomics, and in vivo models to bridge existing gaps in our fragmentary knowledge of how kinases alter neuronal signaling and contribute to disease. By integrating a unique combination of predictive computational frameworks with experimental validation, we aim to uncover how kinases dynamically regulate proteomes in dopamine neurons and how disease-associated mutations alter allostery and rewire kinase-substrate interactions. These findings are expected to advance our understanding of kinase neurobiology, provide insights into neurological disease mechanisms, and pave the way for future therapeutic strategies targeting kinase signaling.
Grant Summary
Neuronal Kinase Signaling in Health and Disease is a NINDS - National Institute of Neurological Disorders and Stroke grant providing up to $620K for university, nonprofit, healthcare org. Applications are due 2031-03-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $620K
2031-03-31
- 1Confirm your organization is eligible for Neuronal Kinase Signaling in Health and Disease from NINDS - National Institute of Neurological Disorders and Stroke, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NINDS - National Institute of Neurological Disorders and Stroke before the deadline.
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Neuronal Kinase Signaling in Health and Disease: Frequently Asked Questions
Who is eligible for the Neuronal Kinase Signaling in Health and Disease?
Neuronal Kinase Signaling in Health and Disease is offered by NINDS - National Institute of Neurological Disorders and Stroke and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Neuronal Kinase Signaling in Health and Disease provide?
Neuronal Kinase Signaling in Health and Disease provides up to $620K per award from NINDS - National Institute of Neurological Disorders and Stroke. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Neuronal Kinase Signaling in Health and Disease deadline?
Applications for Neuronal Kinase Signaling in Health and Disease are due 2031-03-31 (open). Because deadlines can change, verify the date with the funder, NINDS - National Institute of Neurological Disorders and Stroke, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Neuronal Kinase Signaling in Health and Disease?
To apply for Neuronal Kinase Signaling in Health and Disease, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NINDS - National Institute of Neurological Disorders and Stroke.