Acid-Sensing Ion Channel 1a Regulates Synapse-Glioblastoma Integration
NINDS - National Institute of Neurological Disorders and Stroke
About This Grant
PROJECT SUMMARY Glioblastoma (GBM) is one of the most common and deadly brain cancers with a poor prognosis. Recent Cancer Neuroscience findings have revealed bona fide neuron-GBM synapses and their critical roles in driving GBM growth and migration; however, the mechanisms by which the neuron-GBM synapses are modulated remain to be understood. Our preliminary findings suggest a proton (H+) signaling pathway actively mediates neuron-GBM synaptic communications via the Acid-sensing Ion Channel 1a (ASIC1a). Using electrophysiology and genetically engineered mice of ASIC1a, we demonstrate that acid activation of neurons enhances neuron- GBM synaptic communications, and the synaptic response is dependent on the expression of ASIC1a in the brain. Importantly, genetically ablating ASIC1a in glutamatergic neurons reduces GBM burden in vivo and increases mouse survival. Based on preliminary data, our central hypothesis is that GBM TME-induced H+ activates glutamatergic neuronal ASIC1a, strengthens neuron-GBM synaptic transmission, and accelerates GBM progression. The Pan (neuronal activity-dependent gliomagenesis) and Du (H+/ASIC signaling in synaptic transmission) laboratories will work together to address this hypothesis using genetically engineered mice of Asic1a, electrophysiology, advanced microscopy, and various murine and human GBM models. We will address the hypothesis by determining the role of GBM TME-induced extracellular acidification in shaping ASIC1a-dependent neuron-GBM synapse (Aim 1), the effects of the neuron-GBM synapse on GBM cellular functions (Aim 2), and whether glutamatergic neuronal ASIC1a contributes to GBM pathophysiology (Aim 3). Successful completion of these studies will provide important insights into how H+/ASIC1a singling contributes to neuron-GBM synaptic communications and GBM progression and provide new possibilities for treating GBM and related neurological disorders in patients.
Grant Summary
Acid-Sensing Ion Channel 1a Regulates Synapse-Glioblastoma Integration is a NINDS - National Institute of Neurological Disorders and Stroke grant providing up to $634K for university, nonprofit, healthcare org. Applications are due 2031-06-30 (open). Check eligibility and apply with FindGrants.
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Up to $634K
2031-06-30
- 1Confirm your organization is eligible for Acid-Sensing Ion Channel 1a Regulates Synapse-Glioblastoma Integration from NINDS - National Institute of Neurological Disorders and Stroke, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NINDS - National Institute of Neurological Disorders and Stroke before the deadline.
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Acid-Sensing Ion Channel 1a Regulates Synapse-Glioblastoma Integration: Frequently Asked Questions
Who is eligible for the Acid-Sensing Ion Channel 1a Regulates Synapse-Glioblastoma Integration?
Acid-Sensing Ion Channel 1a Regulates Synapse-Glioblastoma Integration is offered by NINDS - National Institute of Neurological Disorders and Stroke and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Acid-Sensing Ion Channel 1a Regulates Synapse-Glioblastoma Integration provide?
Acid-Sensing Ion Channel 1a Regulates Synapse-Glioblastoma Integration provides up to $634K per award from NINDS - National Institute of Neurological Disorders and Stroke. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Acid-Sensing Ion Channel 1a Regulates Synapse-Glioblastoma Integration deadline?
Applications for Acid-Sensing Ion Channel 1a Regulates Synapse-Glioblastoma Integration are due 2031-06-30 (open). Because deadlines can change, verify the date with the funder, NINDS - National Institute of Neurological Disorders and Stroke, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Acid-Sensing Ion Channel 1a Regulates Synapse-Glioblastoma Integration?
To apply for Acid-Sensing Ion Channel 1a Regulates Synapse-Glioblastoma Integration, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NINDS - National Institute of Neurological Disorders and Stroke.