Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions
NINDS - National Institute of Neurological Disorders and Stroke
About This Grant
Abstract/Project Summary As an essential component of most behaviors, the sympathetic system regulates many vital physiological processes, such as heart rate, blood pressure, and respiration. Sympathetic activities exhibit an arousal state- dependent basal level (tone), which is subject to behavioral context-dependent regulation (activation and inactivation). In contrast to its importance, much less is known about top-down sympathetic regulation. Our recent studies reveal several populations of spinal projecting neurons (SPNs) with the capacity to regulate sympathetic preganglionic neurons. We hypothesize that medullary and hypothalamic SPNs may form parallel circuits to control state-dependent sympathetic activities with or without accompanying motor engagement. The objective of this proposed study is to test this hypothesis by analyzing the fundamental circuit architectures of sympathetic controlling SPNs, and determining the roles of these SPNs in regulating the basal tone of sympathetic activity, as well as their response to exercise and pain. The outcomes of this study are expected to advance the fundamental knowledge about autonomic regulation and its health impact.
Grant Summary
Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions is a NINDS - National Institute of Neurological Disorders and Stroke grant providing up to $675K for university, nonprofit, healthcare org. Applications are due 2030-12-31 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $675K
2030-12-31
- 1Confirm your organization is eligible for Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions from NINDS - National Institute of Neurological Disorders and Stroke, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NINDS - National Institute of Neurological Disorders and Stroke before the deadline.
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Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions: Frequently Asked Questions
Who is eligible for the Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions?
Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions is offered by NINDS - National Institute of Neurological Disorders and Stroke and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions provide?
Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions provides up to $675K per award from NINDS - National Institute of Neurological Disorders and Stroke. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions deadline?
Applications for Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions are due 2030-12-31 (open). Because deadlines can change, verify the date with the funder, NINDS - National Institute of Neurological Disorders and Stroke, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions?
To apply for Dissecting Neural Circuits for Top-Down Control of Sympathetic Functions, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NINDS - National Institute of Neurological Disorders and Stroke.