The role of defective pro-viruses and viral proteins in NeuroHIV and cure
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
Abstract: HIV reservoirs are present in several tissues, including the bloodstream, lymphoid, and CNS. However, the nature and mechanisms by which these viral reservoirs are generated and maintained under ART are unknown. The recent development of several techniques to detect, quantify, and characterize viral reservoirs in situ has provided a unique tool to examine these reservoirs. Our laboratory has become a major contributor to detecting rare viral reservoirs in tissues and bloodstream and the effects of drug use on viral reservoir formation and stability. Our imaging systems correspond to correlative microscopy (live-cell, confocal, and electron microscopy), with mass spectrometry imaging and spatial proteomic/mRNA. The combination of all these technologies is unique for infectious diseases. Our data clearly indicates that despite long- term ART and full systemic suppression, synthesis of viral proteins and defective pro-viruses is still occurring even after 26 years in ART. Viral proteins such as tat, gp120, and nef are produced by viral reservoirs and taken up for surrounding uninfected cells, triggering chronic neuro and immune system compromise. Interestingly, sex and drug are critical determinants of residual viral expression and the radius of diffusion of these viral factors. Our proposal is designed in response to the PAR-25-330 with a focus on defective pro-viruses in HIV persistence and pathogenesis during ART.
Grant Summary
The role of defective pro-viruses and viral proteins in NeuroHIV and cure is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $742K for university, nonprofit, healthcare org. Applications are due 2031-04-30 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $742K
2031-04-30
- 1Confirm your organization is eligible for The role of defective pro-viruses and viral proteins in NeuroHIV and cure from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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The role of defective pro-viruses and viral proteins in NeuroHIV and cure: Frequently Asked Questions
Who is eligible for the The role of defective pro-viruses and viral proteins in NeuroHIV and cure?
The role of defective pro-viruses and viral proteins in NeuroHIV and cure is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the The role of defective pro-viruses and viral proteins in NeuroHIV and cure provide?
The role of defective pro-viruses and viral proteins in NeuroHIV and cure provides up to $742K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the The role of defective pro-viruses and viral proteins in NeuroHIV and cure deadline?
Applications for The role of defective pro-viruses and viral proteins in NeuroHIV and cure are due 2031-04-30 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the The role of defective pro-viruses and viral proteins in NeuroHIV and cure?
To apply for The role of defective pro-viruses and viral proteins in NeuroHIV and cure, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.