Parsing the Idiographic NeuroEndocrinology of Suicidality (PINES): A Computational Pharmacologic fMRI Study
About This Grant
Project Summary and Abstract Suicide is a leading cause of death among females of reproductive age, with suicide attempts occurring most frequently around menses (perimenstrually), when estradiol (E2) and progesterone (P4) fall rapidly. Across three recent placebo-controlled crossover clinical trials with female outpatients experiencing suicidality (NCT03720847, NCT04112368, NCT03498313), we have documented that perimenstrual worsening of depression and suicidal ideation can be prevented by stabilizing perimenstrual estradiol (E2) and progesterone (P4) or E2 alone, relative to placebo. The proposed research combines expertise in clinical trials, pharmacologic fMRI acquisition/analysis, E2-related neural mechanisms, and group iterative multiple model estimation (GIMME), in order to advance understanding of the role of ovarian steroids in proximal suicide risk, with the long-term goal of developing diagnostics and treatments for hormonal contributions to suicide. The central aim of the current work is to identify behavioral and neural pathways underlying the anti-suicidality benefits of E2 observed in our prior trials. Design: The proposed study has two parts: a two-month longitudinal baseline with 200 recruited outpatients (150 completers), and a crossover placebo-controlled trial with 75 recruited participants (60 completers) examining E2 administration effects during perimenstrual weeks on symptom and neural networks. Specific Aims: Aim 1 is to identify idiographic hormone-symptom networks associated with proximal suicide risk, using GIMME. In subgroup analyses, we expect at least one group to show no hormonal effects, while other groups will demonstrate networks indicating E2-driven suicidality (linked with depressive symptoms), P4-driven suicidality (linked with irritability and social symptoms), or a combination of both. Aim 2 is to use GIMME to identify person-specific and subgroup-level effects of E2 stabilization on behavioral and neural networks that may explain the benefits of perimenstrual E2 treatment on suicidality. Relevance: By conducting a mechanistic experiment that probes the behavioral and neural mediators of a known cause of acute suicide risk, the research responds to public calls from the NIMH-sponsored Suicide Research Prioritization Agenda to identify modifiable causes of proximal suicide risk. Moreover, this project aligns with NIH’s recently stated interest in research focused on diseases and health conditions that predominantly affect women or are female-specific (NOT-OD-24-079).
Grant Summary
Parsing the Idiographic NeuroEndocrinology of Suicidality (PINES): A Computational Pharmacologic fMRI Study is a NIMH - National Institute of Mental Health grant providing up to $720K for university, nonprofit, healthcare org. Applications are due 2031-04-30 (open). Check eligibility and apply with FindGrants.
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Up to $720K
2031-04-30
- 1Confirm your organization is eligible for Parsing the Idiographic NeuroEndocrinology of Suicidality (PINES): A Computational Pharmacologic fMRI Study from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Parsing the Idiographic NeuroEndocrinology of Suicidality (PINES): A Computational Pharmacologic fMRI Study: Frequently Asked Questions
Who is eligible for the Parsing the Idiographic NeuroEndocrinology of Suicidality (PINES): A Computational Pharmacologic fMRI Study?
Parsing the Idiographic NeuroEndocrinology of Suicidality (PINES): A Computational Pharmacologic fMRI Study is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Parsing the Idiographic NeuroEndocrinology of Suicidality (PINES): A Computational Pharmacologic fMRI Study provide?
Parsing the Idiographic NeuroEndocrinology of Suicidality (PINES): A Computational Pharmacologic fMRI Study provides up to $720K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Parsing the Idiographic NeuroEndocrinology of Suicidality (PINES): A Computational Pharmacologic fMRI Study deadline?
Applications for Parsing the Idiographic NeuroEndocrinology of Suicidality (PINES): A Computational Pharmacologic fMRI Study are due 2031-04-30 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Parsing the Idiographic NeuroEndocrinology of Suicidality (PINES): A Computational Pharmacologic fMRI Study?
To apply for Parsing the Idiographic NeuroEndocrinology of Suicidality (PINES): A Computational Pharmacologic fMRI Study, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.