Regulation of sleep circuits by the Drosophila serotonin transporter
About This Grant
Abstract Serotonin regulates a variety of complex behaviors in both mammals and invertebrates including sleep. The extracellular serotonin level available for signaling to post-synaptic receptors determines the activity of most, if not all underlying circuits. The plasma membrane Serotonin Transporter (SERT) is responsible for reuptake of serotonin after exocytotic release and therefore represents the primary mechanism for regulating extracellular serotonin levels. To date, the mechanisms by a which a decrease in SERT activity and the subsequent increase in extracellular serotonin alters circuit function and behavior remain poorly understood. Drosophila represents a powerful model to address this issue, but the requisite genetic tools have remained underdeveloped. We have addressed this issue by generating new tagged and/or mutant alleles of the Drosophila Serotonin Transporter (dSERT) and a subset of serotonin receptors. In Aim 1 we will use these lines to explore potential heterogeneities in the pathways by which dSERT regulates sleep and determine whether loss of dSERT activity during development can influence adult sleep. Both issues have broad translational relevance. In Aim 2 we will map for the first time, the location of serotonergic autoreceptors in the fly. We will then determine whether a serotonergic autoreceptor we have identified regulates sleep. In Aim 3 we will probe specific subsets of post-synaptic neurons in the mushroom bodies for potential changes in gene expression. We will use genetic tools that surpass the level of detail available in mammalian systems. These data will provide fundamental information about the mechanisms by which SERT can influence a translationally relevant behavior. We speculate that the principles we uncover will be relevant to both sleep as well as other complex behaviors regulated by serotonin and SERT.
Grant Summary
Regulation of sleep circuits by the Drosophila serotonin transporter is a NIMH - National Institute of Mental Health grant providing up to $662K for university, nonprofit, healthcare org. Applications are due 2031-02-28 (open). Check eligibility and apply with FindGrants.
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Up to $662K
2031-02-28
- 1Confirm your organization is eligible for Regulation of sleep circuits by the Drosophila serotonin transporter from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Regulation of sleep circuits by the Drosophila serotonin transporter: Frequently Asked Questions
Who is eligible for the Regulation of sleep circuits by the Drosophila serotonin transporter?
Regulation of sleep circuits by the Drosophila serotonin transporter is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Regulation of sleep circuits by the Drosophila serotonin transporter provide?
Regulation of sleep circuits by the Drosophila serotonin transporter provides up to $662K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Regulation of sleep circuits by the Drosophila serotonin transporter deadline?
Applications for Regulation of sleep circuits by the Drosophila serotonin transporter are due 2031-02-28 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Regulation of sleep circuits by the Drosophila serotonin transporter?
To apply for Regulation of sleep circuits by the Drosophila serotonin transporter, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.