Sex- and hormone-dependent differences in memory vulnerability to acute traumatic stress
About This Grant
Project Summary/Abstract This proposal focuses on the fundamental sex differences in the vulnerability to acute traumatic stress (ATS) and the role of the sex hormone estrogen, and signaling via sex-specific hippocampal receptors, in the enduring memory problems that follow ATS. It is now recognized that acute traumatic events (e.g., mass shooting, earthquakes) may provoke enduring disturbances of hippocampus-dependent memory, and that these problems are more common in women. We leverage robust preliminary data to probe why males, and females at different phases of the estrous cycle, differ in their vulnerabilities to ATS, what these differences are and the mechanisms that drive them. This information will provide important targets for promoting resilience to ATS. We find ATS causes memory disturbances in male (♂) and proestrous female (♀) but not estrous ♀ mice, and the deficits are long-lasting only in proestrous ♀. ♂ and ♀ differ in numerous measures, including in levels of hippocampal estrogens: ♂ and proestrous ♀, both vulnerable to ATS, have high levels of hippocampal estrogen compared with estrous ♀. Estrogen acts via several receptors (ERs) and its enduring effects are thought to result from interactions of ERα or Erβ with the chromatin. Leveraging robust preliminary data we will (1) Test whether ATS-induced memory disturbances require ERα in ♂ and, in contrast, Erβ in ♀ (Aim 1). (2) establish if sex- and Estrogen-level dependent vulnerability to ATS in ♂ and proestrous ♀ mice is a result of sex and hormone-dependent hippocampal chromatin states, which elicit distinct transcriptional programs upon exposure to ATS (Aim 2). (3) use focal conditional ER deletions to test whether the unique vulnerability of proestrous ♀ to persistent ATS-induced memory disturbances results from activation of distinct transcriptional targets of ERβ in ♀ hippocampus. Together, the expected discoveries will illuminate the mechanisms for the fundamental sex differences in vulnerability to enduring trauma-induced memory disturbances and will offer targets for mitigation.
Grant Summary
Sex- and hormone-dependent differences in memory vulnerability to acute traumatic stress is a NIMH - National Institute of Mental Health grant providing up to $802K for university, nonprofit, healthcare org. Applications are due 2031-04-30 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $802K
2031-04-30
- 1Confirm your organization is eligible for Sex- and hormone-dependent differences in memory vulnerability to acute traumatic stress from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Sex- and hormone-dependent differences in memory vulnerability to acute traumatic stress: Frequently Asked Questions
Who is eligible for the Sex- and hormone-dependent differences in memory vulnerability to acute traumatic stress?
Sex- and hormone-dependent differences in memory vulnerability to acute traumatic stress is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Sex- and hormone-dependent differences in memory vulnerability to acute traumatic stress provide?
Sex- and hormone-dependent differences in memory vulnerability to acute traumatic stress provides up to $802K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Sex- and hormone-dependent differences in memory vulnerability to acute traumatic stress deadline?
Applications for Sex- and hormone-dependent differences in memory vulnerability to acute traumatic stress are due 2031-04-30 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Sex- and hormone-dependent differences in memory vulnerability to acute traumatic stress?
To apply for Sex- and hormone-dependent differences in memory vulnerability to acute traumatic stress, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.