Neural Mechanisms of Threat Learning and Avoidance: Adaptive and MaladaptiveBehaviors
NIMH - National Institute of Mental Health
About This Grant
ABSTRACT This project aims to investigate the roles of a newly identified population of neurons in the supramammillary nucleus (SuM) that are essential for threat learning and avoidance behaviors. These neurons are activated by diverse stressors and may play critical roles in threat conditioning and persistent avoidance. The specific aims of this research are to: (1) elucidate the temporal dynamics and causal roles of these neurons during threat learning, avoidance, and extinction using fiber photometry, optogenetics, and behavioral assays; (2) determine whether these neurons selectively excite neuron populations in the nucleus accumbens (NAc) to promote threat avoidance; and (3) reveal the neural types in SuM and which are recruited during threat learning and sustained avoidance using advanced molecular techniques such as Projection-TAGs, barcoded retrograde viruses, and Act-seq with single nucleus RNA sequencing. By characterizing this novel neural circuitry, the project aims to advance our understanding of active coping mechanisms and contribute to the development of new treatments for stress and anxiety-related disorders by identifying potential therapeutic targets.
Grant Summary
Neural Mechanisms of Threat Learning and Avoidance: Adaptive and MaladaptiveBehaviors is a NIMH - National Institute of Mental Health grant providing up to $736K for university, nonprofit, healthcare org. Applications are due 2031-02-28 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $736K
2031-02-28
- 1Confirm your organization is eligible for Neural Mechanisms of Threat Learning and Avoidance: Adaptive and MaladaptiveBehaviors from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
Don't want to draft it yourself?
We'll draft the complete application against NIMH - National Institute of Mental Health's requirements, run a quality review, and email you a submission-ready PDF plus an editable Word doc within 5 business days. Most orders deliver in 24-48 hours. Flat $399, any grant size.
AI Requirement Analysis
Detailed requirements not yet analyzed
Have the NOFO? Paste it below for AI-powered requirement analysis.
Neural Mechanisms of Threat Learning and Avoidance: Adaptive and MaladaptiveBehaviors: Frequently Asked Questions
Who is eligible for the Neural Mechanisms of Threat Learning and Avoidance: Adaptive and MaladaptiveBehaviors?
Neural Mechanisms of Threat Learning and Avoidance: Adaptive and MaladaptiveBehaviors is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Neural Mechanisms of Threat Learning and Avoidance: Adaptive and MaladaptiveBehaviors provide?
Neural Mechanisms of Threat Learning and Avoidance: Adaptive and MaladaptiveBehaviors provides up to $736K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Neural Mechanisms of Threat Learning and Avoidance: Adaptive and MaladaptiveBehaviors deadline?
Applications for Neural Mechanisms of Threat Learning and Avoidance: Adaptive and MaladaptiveBehaviors are due 2031-02-28 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Neural Mechanisms of Threat Learning and Avoidance: Adaptive and MaladaptiveBehaviors?
To apply for Neural Mechanisms of Threat Learning and Avoidance: Adaptive and MaladaptiveBehaviors, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.