Precise Functional Characterization of the Developing Infant Brain using a Clinical 7T MRI Scanner
About This Grant
PROJECT SUMMARY / ABSTRACT It has been hypothesized that some neurodevelopmental disabilities may have roots in early development. This early period is one in which our knowledge regarding brain functional organization is limited, while at the same time is also believed to be critical for identifying deviations from normal developmental trajectories. Therefore, a reliable and precise functional characterization of the human brain during the first year of life could be indispensable in the effort to identify individuals who are likely to show atypical developmental trajectories and would be candidates for early intervention, which is thought to be most effective during this early period where brain plasticity is high. To date, the quantitative neuroimaging data that has been generated during this early developmental period has been limited due to the many technical challenges in obtaining high quality data in this cohort. This has resulted in sub-optimal acquisition and post-processing strategies, which are not catered towards the infant brain, but rather simply adopted from adult studies. The FDA has recently approved 7T MRI for clinical use, however, thus far it has not been used in the U.S. for studying the infant brain due to the lack of vendor support and safety guidelines specific to infants. Our preliminary data demonstrate the potential for 7T MRI to advance developmental neuroimaging to levels that could allow researchers to uncover individual specific developmental trajectories, including atypical trajectories that manifest during these early months. With the proposed techniques we will achieve SNR levels that allow us to push the spatial resolution, while not sacrificing sensitivity, of functional images in the infant to voxel sizes that are 2-4 times smaller compared to conventional 3T approaches, which use spatial resolutions that are not proportional to the smaller infant brain. We will use these technological advances to follow developmental trajectories of infants within their first year of life, including infants with agenesis of the corpus callosum, a group at high risk for atypical developmental outcomes. Our unique team of inter-disciplinary investigators that have expertise in MRI safety, MRI protocol development and optimization, and in developmental research, are uniquely positioned to carry out the aims. Further, we will share our insights, including infant appropriate safety limits, with the growing community of 7T sites, to provide a template for safe and optimal scanning of infants at this high field.
Grant Summary
Precise Functional Characterization of the Developing Infant Brain using a Clinical 7T MRI Scanner is a NIMH - National Institute of Mental Health grant providing up to $615K for university, nonprofit, healthcare org. Applications are due 2031-05-31 (open). Check eligibility and apply with FindGrants.
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Up to $615K
2031-05-31
- 1Confirm your organization is eligible for Precise Functional Characterization of the Developing Infant Brain using a Clinical 7T MRI Scanner from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Precise Functional Characterization of the Developing Infant Brain using a Clinical 7T MRI Scanner: Frequently Asked Questions
Who is eligible for the Precise Functional Characterization of the Developing Infant Brain using a Clinical 7T MRI Scanner?
Precise Functional Characterization of the Developing Infant Brain using a Clinical 7T MRI Scanner is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Precise Functional Characterization of the Developing Infant Brain using a Clinical 7T MRI Scanner provide?
Precise Functional Characterization of the Developing Infant Brain using a Clinical 7T MRI Scanner provides up to $615K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Precise Functional Characterization of the Developing Infant Brain using a Clinical 7T MRI Scanner deadline?
Applications for Precise Functional Characterization of the Developing Infant Brain using a Clinical 7T MRI Scanner are due 2031-05-31 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Precise Functional Characterization of the Developing Infant Brain using a Clinical 7T MRI Scanner?
To apply for Precise Functional Characterization of the Developing Infant Brain using a Clinical 7T MRI Scanner, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.