Integrating molecular and social exposures to understand accelerated aging in cancer patients with HIV in the Southeastern US
NIMHD - National Institute on Minority Health and Health Disparities
About This Grant
MODIFIED PROJECT SUMMARY/ABSTRACT SECTION As a result of effective HIV therapy, the proportion of people with HIV (PWH) living to at least 50 years of age increased from 27% in 2006 to 58% in 2020. An unintended consequence of this aging is that chronic diseases such as cancer are now increasingly common. In the US, PWH with cancer are over twice as likely to die due to cancer compared to cancer patients without HIV, with a disproportionate impact of the US HIV epidemic in the Southeastern US. Herein, we posit that HIV-associated cancer outcomes differences are driven in part by biological changes resulting from exposure to individual-level (e.g., perceived job stress) and neighborhood-level (e.g., proportion of residents below national poverty line) factors (referred to collectively as multi-level stressors). Recent data from our study team demonstrate that, compared to cancer patients without HIV, PWH with cancer have epigenetic (DNA methylation) patterns indicative of accelerated aging and a higher prevalence of somatic mutations that clonally expand in the hematopoietic compartment as individuals age (clonal hematopoiesis). Importantly, each of these genomic aging biomarkers have been associated with inferior survival among PWH with cancer, but their association with multi-level stressors remains unexplored among PWH. We propose to address this research gap, specifically the lack of empirical evidence testing the hypothesis that accelerated aging, stemming from exposure to multi-level stressors, is a mediator of poor cancer outcomes among PWH and cancer in the US. To accomplish this, we will leverage existing infrastructure to prospectively identify 500 cancer patients (250 PWH, 250 people without HIV [PWoH]) from Moffitt Cancer Center and 250 PWH without cancer from an existing partnership with the HIV FIGHTER registry at the University of South Florida. The inclusion of PWH without cancer from FIGHTER, as well as cancer patients without HIV from Moffitt, will help elucidate whether the impact of multi-level social stressors on the genomic aging process is uniquely exacerbated by the presence of both chronic HIV infection and a cancer diagnosis. Our aims are: Aim 1. Examine the association between multi-level stressors and epigenetic age acceleration in the presence of HIV and cancer; Aim 2. Examine the association between multi-level stressors and the prevalence of age-related clonal hematopoiesis in the presence of HIV and cancer; and Aim 3. Estimate direct and indirect effects of multi-level stressors on mortality among PWH and cancer, accounting for the mediating role of accelerated aging. The successful completion of our project will: (1) provide descriptions of the magnitude of the association between multi-level stressors and mortality among PWH with cancer in the US Southeast, which is currently unavailable; (2) elucidate biological mechanisms (accelerated genomic aging) through which multi-level stressors contribute to poor cancer outcomes among PWH; and (3) create a clinic-based cohort with biological specimens, augmented with contextual individual and neighborhood-level data, to support studies on cancer and aging among PWH.
Grant Summary
Integrating molecular and social exposures to understand accelerated aging in cancer patients with HIV in the Southeastern US is a NIMHD - National Institute on Minority Health and Health Disparities grant providing up to $812K for university, nonprofit, healthcare org. Applications are due 2030-12-31 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $812K
2030-12-31
- 1Confirm your organization is eligible for Integrating molecular and social exposures to understand accelerated aging in cancer patients with HIV in the Southeastern US from NIMHD - National Institute on Minority Health and Health Disparities, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMHD - National Institute on Minority Health and Health Disparities before the deadline.
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Integrating molecular and social exposures to understand accelerated aging in cancer patients with HIV in the Southeastern US: Frequently Asked Questions
Who is eligible for the Integrating molecular and social exposures to understand accelerated aging in cancer patients with HIV in the Southeastern US?
Integrating molecular and social exposures to understand accelerated aging in cancer patients with HIV in the Southeastern US is offered by NIMHD - National Institute on Minority Health and Health Disparities and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Integrating molecular and social exposures to understand accelerated aging in cancer patients with HIV in the Southeastern US provide?
Integrating molecular and social exposures to understand accelerated aging in cancer patients with HIV in the Southeastern US provides up to $812K per award from NIMHD - National Institute on Minority Health and Health Disparities. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Integrating molecular and social exposures to understand accelerated aging in cancer patients with HIV in the Southeastern US deadline?
Applications for Integrating molecular and social exposures to understand accelerated aging in cancer patients with HIV in the Southeastern US are due 2030-12-31 (open). Because deadlines can change, verify the date with the funder, NIMHD - National Institute on Minority Health and Health Disparities, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Integrating molecular and social exposures to understand accelerated aging in cancer patients with HIV in the Southeastern US?
To apply for Integrating molecular and social exposures to understand accelerated aging in cancer patients with HIV in the Southeastern US, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMHD - National Institute on Minority Health and Health Disparities.