PRIME: Placental Immune Response and Impact on Maternal-Infant Health
NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development
About This Grant
Project Summary While antiretroviral therapy (ART) has drastically reduced mother-to-child HIV transmission, increasing evidence suggests that in utero ART exposure can disrupt fetal immune development and placental function—even in the absence of vertical infection. HIV-exposed uninfected (HEU) infants experience higher rates of preterm birth, growth restriction, and immune dysregulation, yet the mechanisms remain poorly understood. Addressing these gaps is critical for reducing long-term immune-mediated morbidity in this growing population. Our central hypothesis is that ART exposure reprograms immune signaling at the maternal-fetal interface (MFI), creating a pro-inflammatory environment that impairs immune tolerance and fetal immune maturation. In response to PAR- 25-362, we propose a multi-pronged investigation into how ART influences immune cell development, antigen presentation, and extracellular vesicle (EV)-mediated communication at the MFI. Our study will use cutting-edge immunopeptidomics, transcriptomics, and functional co-culture assays to define how ART disrupts key regulatory mechanisms at the placenta. This work will generate mechanistic insights into immune dysregulation in HEU infants and inform safer therapeutic strategies during pregnancy.
Grant Summary
PRIME: Placental Immune Response and Impact on Maternal-Infant Health is a NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development grant providing up to $2.5M for university, nonprofit, healthcare org. Applications are due 2030-05-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $2.5M
2030-05-31
- 1Confirm your organization is eligible for PRIME: Placental Immune Response and Impact on Maternal-Infant Health from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development before the deadline.
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PRIME: Placental Immune Response and Impact on Maternal-Infant Health: Frequently Asked Questions
Who is eligible for the PRIME: Placental Immune Response and Impact on Maternal-Infant Health?
PRIME: Placental Immune Response and Impact on Maternal-Infant Health is offered by NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the PRIME: Placental Immune Response and Impact on Maternal-Infant Health provide?
PRIME: Placental Immune Response and Impact on Maternal-Infant Health provides up to $2.5M per award from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the PRIME: Placental Immune Response and Impact on Maternal-Infant Health deadline?
Applications for PRIME: Placental Immune Response and Impact on Maternal-Infant Health are due 2030-05-31 (open). Because deadlines can change, verify the date with the funder, NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the PRIME: Placental Immune Response and Impact on Maternal-Infant Health?
To apply for PRIME: Placental Immune Response and Impact on Maternal-Infant Health, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development.