Detection of Preeclampsia and Fetal Growth Restriction Based on Simultaneous Assessment of Maternal and Fetal Blood Flow Components
NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development
About This Grant
Abstract Placental blood flow analysis is complicated by having both maternal and fetal flow components. Using spectral analysis of the umbilical venous pulse wave spectral envelope, i.e., second order spectral analysis, we have been able to simultaneously assess maternal/fetal blood flow in the placenta, and we have shown preliminarily that normal and fetal growth restriction (FGR)/preeclamptic (PE) pregnancies can be distinguished. Early diagnosis and subsequent management of FGR and PE remains a significant clinical challenge. The ability to measure changes in placental blood flow safely and longitudinally, using a non-invasive ultrasound technique would provide early insight into pregnancies at risk and could be widely deployed in obstetrical care settings. These diagnoses would permit early initiation of preventative strategies and the ability to test therapeutic interventions to lessen the severity of disease in real time. This study will include normal gestations and gestations with FGR and/or preeclampsia. Umbilical vein pulse wave spectra will be acquired, and spectral envelopes identified as a function of time and analyzed by Fourier Transforms. Logarithms of the ratios of the maternal/fetal spectral peaks (LRSP) will be compared in normal and FGR/preeclamptic populations. Umbilical venous flow will be obtained by our established and standardized 3D color flow (3DCF) methodology. Our preliminary data using multivariate analysis shows significant population-based differentiation of the above conditions. In this proposed study we will attempt to reach diagnostic value, i.e., case-by-case differentiation, by means of these two specific aims: AIM 1. Determine the temporal characteristics of 3DCF and LRSP in a longitudinal study. AIM 2. Determine correlations of PE and FGR onset with cord blood flow and LRSP in a cross-sectional study If successful, this study will show that umbilical venous flow contains markers related to placental maternal/fetal blood flow, which can be used to assess FGR and preeclampsia. When coupled with umbilical cord blood flow, this new marker may potentially identify the primary causes of the two conditions. Our method is fast, safe, easy and could be quickly introduced into standard obstetrical ultrasound examinations.
Grant Summary
Detection of Preeclampsia and Fetal Growth Restriction Based on Simultaneous Assessment of Maternal and Fetal Blood Flow Components is a NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development grant providing up to $599K for university, nonprofit, healthcare org. Applications are due 2031-06-30 (open). Check eligibility and apply with FindGrants.
Not quite the right fit?
Search 9,000+ open grants, or get matches ranked for your organization — free.
Focus Areas
Eligibility
How to Apply
Up to $599K
2031-06-30
- 1Confirm your organization is eligible for Detection of Preeclampsia and Fetal Growth Restriction Based on Simultaneous Assessment of Maternal and Fetal Blood Flow Components from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development before the deadline.
Don't want to draft it yourself?
We'll draft the complete application against NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development's requirements, run a quality review, and email you a submission-ready PDF plus an editable Word doc within 5 business days. Most orders deliver in 24-48 hours. Flat $399, any grant size.
AI Requirement Analysis
Detailed requirements not yet analyzed
Have the NOFO? Paste it below for AI-powered requirement analysis.
Detection of Preeclampsia and Fetal Growth Restriction Based on Simultaneous Assessment of Maternal and Fetal Blood Flow Components: Frequently Asked Questions
Who is eligible for the Detection of Preeclampsia and Fetal Growth Restriction Based on Simultaneous Assessment of Maternal and Fetal Blood Flow Components?
Detection of Preeclampsia and Fetal Growth Restriction Based on Simultaneous Assessment of Maternal and Fetal Blood Flow Components is offered by NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Detection of Preeclampsia and Fetal Growth Restriction Based on Simultaneous Assessment of Maternal and Fetal Blood Flow Components provide?
Detection of Preeclampsia and Fetal Growth Restriction Based on Simultaneous Assessment of Maternal and Fetal Blood Flow Components provides up to $599K per award from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Detection of Preeclampsia and Fetal Growth Restriction Based on Simultaneous Assessment of Maternal and Fetal Blood Flow Components deadline?
Applications for Detection of Preeclampsia and Fetal Growth Restriction Based on Simultaneous Assessment of Maternal and Fetal Blood Flow Components are due 2031-06-30 (open). Because deadlines can change, verify the date with the funder, NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Detection of Preeclampsia and Fetal Growth Restriction Based on Simultaneous Assessment of Maternal and Fetal Blood Flow Components?
To apply for Detection of Preeclampsia and Fetal Growth Restriction Based on Simultaneous Assessment of Maternal and Fetal Blood Flow Components, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development.