Dietary Reversal of the Reprometabolic Syndrome
NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development
About This Grant
PROJECT SUMMARY/ABSTRACT In addition to reduced fecundability, women with obesity have an increased risk for pregnancy loss, and reduced live birth rates with fertility treatment, and increased perinatal complications compared to women with a BMI of 25 kg/m2 or less. Behavioral weight loss has not been successful in either improving fertility or reducing pregnancy complications. Therefore, other approaches are needed to address the reproductive deficit associated with obesity and to optimally prepare obese women for the healthiest possible pregnancy. We and others have characterized detrimental effects of female obesity on the hypothalamic-pituitary-ovarian axis, consisting of reduced luteal progesterone production and a decreased pituitary response to gonadotropin releasing hormone, a condition we have termed the Reprometabolic Syndrome. Work from our lab has shown that these key features of the Reprometabolic Syndrome can be induced in women with a BMI of 18-25 kg/m2 by administering a eucaloric, high fat diet (48% calories from fat) for one month. The current study proposes to test the hypothesis that the Reprometabolic Syndrome's endocrine features can be improved in women with obesity who consume a low fat (22% calories from fat), nutritionally balanced, eucaloric diet for one month. In Aim 1, we will evaluate daily urinary LH, FSH, estrone conjugates (E1c) and pregnanediol glucuronide (Pdg) in 30 women with a BMI of 30 kg/m2 or greater over four consecutive menstrual cycles before and after consumption of the low-fat diet to determine luteal progesterone metabolite production with the option for a long-term extension study. In Aim 2, we will perform early follicular phase frequent blood sampling over 3 hours in 24 women to determine LH and FSH baseline secretion and response to a weight based 75 ng/kg physiologic bolus of GnRH in the cycle preceding the low-fat diet and again in the subsequent cycle at the end of the low-fat diet. We will assess mean gonadotropin levels and response to GnRH. Aim 3 will examine metabolomic and microbiome profiles before and at the end of the low-fat diet to assess for salutary changes in free fatty acids, markers of mitochondrial function, oxidative stress and glutathione homeostasis, as well as microbial diversity, as a result of the dietary intervention. The potential for a relatively straightforward dietary intervention to improve fertility parameters in women with obesity would represent a readily scalable health benefit that could eventually be incorporated into an overall, evidence-based preconceptional health plan that will allow women with obesity to minimize risks to themselves, their pregnancy and their offspring.
Grant Summary
Dietary Reversal of the Reprometabolic Syndrome is a NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development grant providing up to $330K for university, nonprofit, healthcare org. Applications are due 2031-06-30 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $330K
2031-06-30
- 1Confirm your organization is eligible for Dietary Reversal of the Reprometabolic Syndrome from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development before the deadline.
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Dietary Reversal of the Reprometabolic Syndrome: Frequently Asked Questions
Who is eligible for the Dietary Reversal of the Reprometabolic Syndrome?
Dietary Reversal of the Reprometabolic Syndrome is offered by NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Dietary Reversal of the Reprometabolic Syndrome provide?
Dietary Reversal of the Reprometabolic Syndrome provides up to $330K per award from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Dietary Reversal of the Reprometabolic Syndrome deadline?
Applications for Dietary Reversal of the Reprometabolic Syndrome are due 2031-06-30 (open). Because deadlines can change, verify the date with the funder, NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Dietary Reversal of the Reprometabolic Syndrome?
To apply for Dietary Reversal of the Reprometabolic Syndrome, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development.