Genetic and neuronal basis of behavioral variation in responses to social isolation
About This Grant
Summary Animals, from humans to flies, thrive with social interactions and suffer significant adverse mental and physical health consequences when isolated. In mammals, social isolation increases aggression, contributes to neuropsychiatric and neurodegenerative conditions, and disrupts sleep, memory, and attention. Yet, responses to isolation vary among individuals, populations, and species. How environmental and genetic constraints shape these individual responses remains poorly defined. Emerging data show that experience-dependent changes in gene regulation, neuromodulation, and behavioral modifications are linked. How variation among these mechanisms leads to variation in social experience-dependent behavior remains unclear. This proposal addresses this question by defining the molecular and neural circuit basis of individual susceptibility to the adverse mental and physical effects of social isolation. In previous studies, we showed that social experience alters transcriptional cascades in the brain to reprogram circadian genes to contribute to the modulation of behaviors in response to social experience. In preliminary studies, we identified individuals from specific population with variation in their behavioral and brain gene expression responses to social experience and determined candidate genes with synaptic and neuromodulatory functions driving the variation. The project aims to interrogate behavioral variation among individuals across populations in depth and identify molecular and circuit mechanisms driving this variation. Data from genomic, transcriptional, and neuronal patterns will be integrated to reveal patterns associated with behavioral variation. Causal links will be established between candidate gene expression, regulatory elements, and variation in behavioral responses to social isolation. The genes and mechanisms revealed from these studies will inform how natural genetic variation influences neuronal pathways to modulate plasticity of the responses to social experience.
Grant Summary
Genetic and neuronal basis of behavioral variation in responses to social isolation is a NIGMS - National Institute of General Medical Sciences grant providing up to $339K for university, nonprofit, healthcare org. Applications are due 2030-05-31 (open). Check eligibility and apply with FindGrants.
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Up to $339K
2030-05-31
- 1Confirm your organization is eligible for Genetic and neuronal basis of behavioral variation in responses to social isolation from NIGMS - National Institute of General Medical Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIGMS - National Institute of General Medical Sciences before the deadline.
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Genetic and neuronal basis of behavioral variation in responses to social isolation: Frequently Asked Questions
Who is eligible for the Genetic and neuronal basis of behavioral variation in responses to social isolation?
Genetic and neuronal basis of behavioral variation in responses to social isolation is offered by NIGMS - National Institute of General Medical Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Genetic and neuronal basis of behavioral variation in responses to social isolation provide?
Genetic and neuronal basis of behavioral variation in responses to social isolation provides up to $339K per award from NIGMS - National Institute of General Medical Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Genetic and neuronal basis of behavioral variation in responses to social isolation deadline?
Applications for Genetic and neuronal basis of behavioral variation in responses to social isolation are due 2030-05-31 (open). Because deadlines can change, verify the date with the funder, NIGMS - National Institute of General Medical Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Genetic and neuronal basis of behavioral variation in responses to social isolation?
To apply for Genetic and neuronal basis of behavioral variation in responses to social isolation, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIGMS - National Institute of General Medical Sciences.