Development of technologies for elucidating the function of cryptic intergenic regions within genomes
NIGMS - National Institute of General Medical Sciences
About This Grant
ABSTRACT This project aims to revolutionize genome annotation by creating new technologies to detect and annotate genomic features currently hidden within intergenic regions. Intergenic features are underexplored and often overlooked by popular genome annotation software despite their vital importance to genome functioning. For example, existing automatic annotation programs miss small proteins due to minimum size cutoffs and are unable to detect non-coding RNAs that are unrepresented in curated databases. These omissions leave the appearance of empty intergenic space that, in fact, contains genomic features. The problem of incomplete annotations is particularly acute for prokaryotic genomes, which are immensely diverse and heavily reliant on automated annotations. This proposal seeks to overcome current limitations, such as the difficulty of detecting ambiguous or rare features, by leveraging machine learning, comparative genomics, and new methodologies for identifying non-coding RNAs, small proteins, and regulatory elements. The proposed technologies will not only improve the accuracy of genome annotations but also enable the discovery of new genomic features that could have significant implications for biomedical research, including the identification of new drug targets. In Aim 1, we will develop a program for finding protein coding genes in prokaryotic genomes that draws upon novel signatures of true genes to improve accuracy over existing methods. In Aim 2, we will identify undiscovered non-coding RNAs by leveraging machine learning with creative signals that differentiate non- coding RNAs from intergenic space. In Aim 3, we will apply comparative genomics methods to clarify the probable function of enigmatic non-coding RNAs. Collectively, these technologies will shed light on unannotated intergenic space and democratize genome annotation by providing an advanced software for comprehensively annotating a broader range of organisms.
Grant Summary
Development of technologies for elucidating the function of cryptic intergenic regions within genomes is a NIGMS - National Institute of General Medical Sciences grant providing up to $1.9M for university, nonprofit, healthcare org. Applications are due 2030-05-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $1.9M
2030-05-31
- 1Confirm your organization is eligible for Development of technologies for elucidating the function of cryptic intergenic regions within genomes from NIGMS - National Institute of General Medical Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIGMS - National Institute of General Medical Sciences before the deadline.
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Development of technologies for elucidating the function of cryptic intergenic regions within genomes: Frequently Asked Questions
Who is eligible for the Development of technologies for elucidating the function of cryptic intergenic regions within genomes?
Development of technologies for elucidating the function of cryptic intergenic regions within genomes is offered by NIGMS - National Institute of General Medical Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Development of technologies for elucidating the function of cryptic intergenic regions within genomes provide?
Development of technologies for elucidating the function of cryptic intergenic regions within genomes provides up to $1.9M per award from NIGMS - National Institute of General Medical Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Development of technologies for elucidating the function of cryptic intergenic regions within genomes deadline?
Applications for Development of technologies for elucidating the function of cryptic intergenic regions within genomes are due 2030-05-31 (open). Because deadlines can change, verify the date with the funder, NIGMS - National Institute of General Medical Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Development of technologies for elucidating the function of cryptic intergenic regions within genomes?
To apply for Development of technologies for elucidating the function of cryptic intergenic regions within genomes, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIGMS - National Institute of General Medical Sciences.