Discovery and Functional Validation of Hepatic eQTLs
About This Grant
Project Summary Currently, many genome-wide association studies (GWAS) show that single nucleotide polymorphisms (SNPs) associated with drug response and drug metabolism are in non-coding regions of the genome, requiring multi- omic data to better ascertain function. Multi-omic data exist for populations of European ancestry and have been used extensively to elucidate the target genes of associated SNPs through studies of expression quantitative trait loci (eQTLs). However, population diversity within publicly available multi-omic databases is sorely lacking, limiting the ability to utilize the greater diversity in African Ancestry populations to enable discovery for all populations. Our work will fill this gap. We plan to 1) Identify regulatory variants affecting drug-metabolizing enzymes using multi-omics data gathered in hepatocytes, 2) Determine the function of eQTLs via a massively parallel reporter assay in HepG2 and 3) Investigate the effect of eQTLs on the enzyme activity of drug- metabolizing enzymes via prime editing. The need for more predictive biomarkers is clear, and our work will fill this gap.
Grant Summary
Discovery and Functional Validation of Hepatic eQTLs is a NIGMS - National Institute of General Medical Sciences grant providing up to $356K for university, nonprofit, healthcare org. Applications are due 2030-03-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $356K
2030-03-31
- 1Confirm your organization is eligible for Discovery and Functional Validation of Hepatic eQTLs from NIGMS - National Institute of General Medical Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIGMS - National Institute of General Medical Sciences before the deadline.
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Discovery and Functional Validation of Hepatic eQTLs: Frequently Asked Questions
Who is eligible for the Discovery and Functional Validation of Hepatic eQTLs?
Discovery and Functional Validation of Hepatic eQTLs is offered by NIGMS - National Institute of General Medical Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Discovery and Functional Validation of Hepatic eQTLs provide?
Discovery and Functional Validation of Hepatic eQTLs provides up to $356K per award from NIGMS - National Institute of General Medical Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Discovery and Functional Validation of Hepatic eQTLs deadline?
Applications for Discovery and Functional Validation of Hepatic eQTLs are due 2030-03-31 (open). Because deadlines can change, verify the date with the funder, NIGMS - National Institute of General Medical Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Discovery and Functional Validation of Hepatic eQTLs?
To apply for Discovery and Functional Validation of Hepatic eQTLs, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIGMS - National Institute of General Medical Sciences.