Inline impedance-activated recognition, tracking and sorting system on single-cell biophysical metrics
NIGMS - National Institute of General Medical Sciences
About This Grant
Phenotypic plasticity is common for cell types with multiple functions, but there are few label-free tools capable of dynamic tracking of cell phenotypes to quantify their heterogeneity and sort their subpopulations. Biophysical phenotypes undergo dynamic alterations as cells navigate through their functions, but their utilization to monitor plasticity is limited by the lack of high throughput tools for multiparametric cell recognition and activated sorting. For advancing near real-time single-cell recognition based on multiparametric biophysical metrics and activated sorting to isolate specific phenotypes, this application will integrate neural networks to couple the accuracy of image data for discerning intricate cell shapes under deformation, to the speed of impedance signal processing, so that identifying multiparametric cellular metrics of deformability, viability, and electrical physiology can be extracted in near-real-time to activate sorting. This impedance-activated recognition, tracking, and sorting (IARTS) system will be validated with model samples to optimize recognition and sorting throughputs by determining optimal deformation geometries, flow rates, trigger methods and sorting parameters, for application to complex heterogeneous samples for label-free selection and molecular profiling of phenotypically plastic cells.
Grant Summary
Inline impedance-activated recognition, tracking and sorting system on single-cell biophysical metrics is a NIGMS - National Institute of General Medical Sciences grant providing up to $1.1M for university, nonprofit, healthcare org. Applications are due 2030-02-28 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $1.1M
2030-02-28
- 1Confirm your organization is eligible for Inline impedance-activated recognition, tracking and sorting system on single-cell biophysical metrics from NIGMS - National Institute of General Medical Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIGMS - National Institute of General Medical Sciences before the deadline.
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Inline impedance-activated recognition, tracking and sorting system on single-cell biophysical metrics: Frequently Asked Questions
Who is eligible for the Inline impedance-activated recognition, tracking and sorting system on single-cell biophysical metrics?
Inline impedance-activated recognition, tracking and sorting system on single-cell biophysical metrics is offered by NIGMS - National Institute of General Medical Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Inline impedance-activated recognition, tracking and sorting system on single-cell biophysical metrics provide?
Inline impedance-activated recognition, tracking and sorting system on single-cell biophysical metrics provides up to $1.1M per award from NIGMS - National Institute of General Medical Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Inline impedance-activated recognition, tracking and sorting system on single-cell biophysical metrics deadline?
Applications for Inline impedance-activated recognition, tracking and sorting system on single-cell biophysical metrics are due 2030-02-28 (open). Because deadlines can change, verify the date with the funder, NIGMS - National Institute of General Medical Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Inline impedance-activated recognition, tracking and sorting system on single-cell biophysical metrics?
To apply for Inline impedance-activated recognition, tracking and sorting system on single-cell biophysical metrics, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIGMS - National Institute of General Medical Sciences.