A novel lymphatic pathway for ocular aqueous humor drainage
About This Grant
Project Summary Glaucoma is a leading cause of blindness affecting 80 million people worldwide. The mechanisms underlying glaucoma have been studied extensively but are not yet fully understood. Our lab has a long-term interest in ocular lymphatic research. This project is based on our recent discovery of a new aqueous humor outflow pathway that drains from the Schlemm’s canal to conjunctival lymphatic vessels. This new lymphatic outflow pathway is distinctive from the conventional pathway where aqueous humor drains from the Schlemm’s canal to episcleral veins, which are blood vessels. This novel discovery offers a new concept to study ocular fluid drainage and the pathogenesis and treatment of ocular hypertension and glaucoma. The goal of this proposal is to further investigate this novel discovery and to develop new strategies to treat ocular hypertension and glaucoma. Our hypothesis is that the conjunctival lymphatic outflow pathway plays an important role in aqueous humor drainage. Its modulation can lower intraocular pressure and treat glaucoma. This project is based on a large amount of preliminary data and the most recent advances in science and technology. Our specific aims are to 1) assess the specific role of the conjunctival lymphatic pathway in aqueous humor drainage and IOP regulation; 2) investigate the effects of pro-lymphatic treatment on the conjunctival lymphatic pathway; and 3) explore the effects of pro-lymphatic treatment on ocular hypertension and glaucoma. Our study promises to reveal novel mechanisms and therapeutic strategies for glaucoma, and possibly other lymphatic-related diseases in the body.
Grant Summary
A novel lymphatic pathway for ocular aqueous humor drainage is a NEI - National Eye Institute grant providing up to $634K for university, nonprofit, healthcare org. Applications are due 2028-06-30 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $634K
2028-06-30
- 1Confirm your organization is eligible for A novel lymphatic pathway for ocular aqueous humor drainage from NEI - National Eye Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NEI - National Eye Institute before the deadline.
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A novel lymphatic pathway for ocular aqueous humor drainage: Frequently Asked Questions
Who is eligible for the A novel lymphatic pathway for ocular aqueous humor drainage?
A novel lymphatic pathway for ocular aqueous humor drainage is offered by NEI - National Eye Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the A novel lymphatic pathway for ocular aqueous humor drainage provide?
A novel lymphatic pathway for ocular aqueous humor drainage provides up to $634K per award from NEI - National Eye Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the A novel lymphatic pathway for ocular aqueous humor drainage deadline?
Applications for A novel lymphatic pathway for ocular aqueous humor drainage are due 2028-06-30 (open). Because deadlines can change, verify the date with the funder, NEI - National Eye Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the A novel lymphatic pathway for ocular aqueous humor drainage?
To apply for A novel lymphatic pathway for ocular aqueous humor drainage, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NEI - National Eye Institute.