Development of a Label-Free Optical Probe for In Situ Quantification of Cervical Remodeling in Pregnancy
NIBIB - National Institute of Biomedical Imaging and Bioengineering
About This Grant
Project Summary Preterm birth (PTB) is a significant global health concern. The incidence of PTB in both developed and developing countries ranges from 11% to 15%. Despite ongoing research into its causes and treatments, the incidence of PTB has not shown any substantial decline in the past decade. One of the challenges in treating PTB is the lack of accurate and quantifiable methods to predict the onset of labor. It is known that the uterine cervix of a pregnant woman undergoes physiological changes throughout pregnancy that precede delivery. Recent studies in humans and animals suggest that inappropriate alterations in the extracellular matrix of the cervix, along with changes in its molecular content, occur prior to PTB. However, there is currently no method to visualize and assess these changes during pregnancy. In this proposal, we aim to develop a non-invasive, polarization-sensitive optical imaging probe to specifically evaluate cervical collagen changes during pregnancy, alongside shifts in molecular content, both of which are characteristics associated with PTB. We will achieve this objective by addressing three specific aims. In Aim 1, we will develop a miniaturized optical probe capable of delivering images of polarization-sensitive second harmonic generation and two-photon fluorescence microscopy of the uterine cervix in vivo at unmatched resolution. In Aim 2, we will conduct a longitudinal study using an animal model to quantify the changes resulting from the remodeling of the cervix from day 0 of pregnancy to day 19, as well as postpartum for 4 days. Finally, in Aim 3, we will utilize two models of preterm birth: the infection-mediated lipopolysaccharide (LPS) and the progesterone receptor antagonist, mifepristone (RU486), to characterize cervical remodeling associated with preterm labor. This proposal will provide, for the first time, a complete understanding of the remodeling of the uterine cervix in the murine model, paving the way for the development of new methodologies for assessing preterm birth risk.
Grant Summary
Development of a Label-Free Optical Probe for In Situ Quantification of Cervical Remodeling in Pregnancy is a NIBIB - National Institute of Biomedical Imaging and Bioengineering grant providing up to $328K for university, nonprofit, healthcare org. Applications are due 2030-03-31 (open). Check eligibility and apply with FindGrants.
Not quite the right fit?
Search 9,000+ open grants, or get matches ranked for your organization — free.
Focus Areas
Eligibility
How to Apply
Up to $328K
2030-03-31
- 1Confirm your organization is eligible for Development of a Label-Free Optical Probe for In Situ Quantification of Cervical Remodeling in Pregnancy from NIBIB - National Institute of Biomedical Imaging and Bioengineering, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIBIB - National Institute of Biomedical Imaging and Bioengineering before the deadline.
Don't want to draft it yourself?
We'll draft the complete application against NIBIB - National Institute of Biomedical Imaging and Bioengineering's requirements, run a quality review, and email you a submission-ready PDF plus an editable Word doc within 5 business days. Most orders deliver in 24-48 hours. Flat $399, any grant size.
AI Requirement Analysis
Detailed requirements not yet analyzed
Have the NOFO? Paste it below for AI-powered requirement analysis.
Development of a Label-Free Optical Probe for In Situ Quantification of Cervical Remodeling in Pregnancy: Frequently Asked Questions
Who is eligible for the Development of a Label-Free Optical Probe for In Situ Quantification of Cervical Remodeling in Pregnancy?
Development of a Label-Free Optical Probe for In Situ Quantification of Cervical Remodeling in Pregnancy is offered by NIBIB - National Institute of Biomedical Imaging and Bioengineering and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Development of a Label-Free Optical Probe for In Situ Quantification of Cervical Remodeling in Pregnancy provide?
Development of a Label-Free Optical Probe for In Situ Quantification of Cervical Remodeling in Pregnancy provides up to $328K per award from NIBIB - National Institute of Biomedical Imaging and Bioengineering. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Development of a Label-Free Optical Probe for In Situ Quantification of Cervical Remodeling in Pregnancy deadline?
Applications for Development of a Label-Free Optical Probe for In Situ Quantification of Cervical Remodeling in Pregnancy are due 2030-03-31 (open). Because deadlines can change, verify the date with the funder, NIBIB - National Institute of Biomedical Imaging and Bioengineering, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Development of a Label-Free Optical Probe for In Situ Quantification of Cervical Remodeling in Pregnancy?
To apply for Development of a Label-Free Optical Probe for In Situ Quantification of Cervical Remodeling in Pregnancy, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIBIB - National Institute of Biomedical Imaging and Bioengineering.