Active Biointegrated Living Electronics (ABLE) for Synergistic Treatment of Skin Inflammation
NIBIB - National Institute of Biomedical Imaging and Bioengineering
About This Grant
Project Summary Living materials—biohybrids combining both biological and synthetic components—exhibit dynamic responses to environmental stimuli and closely resemble native biological tissues, positioning them for transformative biomedical applications. This proposal introduces the second-generation Active Biointegrated Living Electronics (ABLE) system, designed specifically to manage and treat psoriasis through the integration of living materials and state-of-the-art bioelectronic technologies. The ABLE system consists of biocompatible hydrogel composites enriched with the commensal bacterium Staphylococcus epidermidis, coupled with a flexible, wireless bioelectronic device. This integrated platform continuously monitors critical skin parameters, including pH, temperature, inflammatory biomarkers, and tissue impedance, and delivers precise, adaptive electrical stimulation for effective inflammation management. In Aim 1, we will engineer and thoroughly characterize foundational living bioelectronic components by creating hydrogel matrices that mimic the extracellular matrix, supporting robust bacterial viability and metabolic function. Concurrently, we will develop flexible printed circuit boards (FPCB) equipped with energy-harvesting antennas, microcontrollers, multimodal sensors, and stimulation electrodes. These integrated systems will facilitate seamless bioelectronic interfacing, enabling real-time data acquisition and precise control of biological responses. Aim 2 focuses on systematically mapping and optimizing device parameters through detailed in vitro studies. We will elucidate how electrical modulation influences microbial physiology, including membrane potentials, ion fluxes, metabolic activities, and extracellular vesicle production. These studies will provide critical insights into microbial function and biofilm dynamics, guiding the identification of optimal electrical stimulation parameters necessary for therapeutic applications. Aim 3 will rigorously validate the therapeutic efficacy of the ABLE platform in vivo using a clinically relevant animal model of psoriasis. By combining advanced bioelectronics with commensal bacteria-based hydrogels, we will comprehensively assess therapeutic outcomes through histological analyses, cytokine profiling, transcriptomics, microbiome analysis, and detailed characterization of T-cell subsets. This multifaceted evaluation aims to establish a clear mechanistic understanding of the microbial- electrical interactions and demonstrate the potential clinical relevance of the ABLE platform. Our integrative approach not only offers fundamental insights into bioelectronic modulation of skin microbiota and immune responses but also sets the stage for groundbreaking translational applications, revolutionizing inflammation management and treatment paradigms in personalized medicine. The proposed ABLE system is poised to significantly advance healthcare innovation by enabling precise, minimally invasive, and adaptive therapeutic strategies for chronic inflammatory skin conditions.
Grant Summary
Active Biointegrated Living Electronics (ABLE) for Synergistic Treatment of Skin Inflammation is a NIBIB - National Institute of Biomedical Imaging and Bioengineering grant providing up to $641K for university, nonprofit, healthcare org. Applications are due 2030-06-30 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $641K
2030-06-30
- 1Confirm your organization is eligible for Active Biointegrated Living Electronics (ABLE) for Synergistic Treatment of Skin Inflammation from NIBIB - National Institute of Biomedical Imaging and Bioengineering, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIBIB - National Institute of Biomedical Imaging and Bioengineering before the deadline.
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Active Biointegrated Living Electronics (ABLE) for Synergistic Treatment of Skin Inflammation: Frequently Asked Questions
Who is eligible for the Active Biointegrated Living Electronics (ABLE) for Synergistic Treatment of Skin Inflammation?
Active Biointegrated Living Electronics (ABLE) for Synergistic Treatment of Skin Inflammation is offered by NIBIB - National Institute of Biomedical Imaging and Bioengineering and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Active Biointegrated Living Electronics (ABLE) for Synergistic Treatment of Skin Inflammation provide?
Active Biointegrated Living Electronics (ABLE) for Synergistic Treatment of Skin Inflammation provides up to $641K per award from NIBIB - National Institute of Biomedical Imaging and Bioengineering. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Active Biointegrated Living Electronics (ABLE) for Synergistic Treatment of Skin Inflammation deadline?
Applications for Active Biointegrated Living Electronics (ABLE) for Synergistic Treatment of Skin Inflammation are due 2030-06-30 (open). Because deadlines can change, verify the date with the funder, NIBIB - National Institute of Biomedical Imaging and Bioengineering, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Active Biointegrated Living Electronics (ABLE) for Synergistic Treatment of Skin Inflammation?
To apply for Active Biointegrated Living Electronics (ABLE) for Synergistic Treatment of Skin Inflammation, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIBIB - National Institute of Biomedical Imaging and Bioengineering.