Sound Asleep: Technologies for uninterrupted whole night sleep recording in an MRI scanner
NIBIB - National Institute of Biomedical Imaging and Bioengineering
About This Grant
Abstract The project aims to develop a platform that would enable whole-brain functional MRI (fMRI) during full night natural sleep in-sync to polysomnographic recordings (PSG), nearly as easily as in a PSG-only sleep lab. Sleep is vital for maintaining all aspects of human health. Extensive research has confirmed its role in homeostatic processes that are critical for brain health, especially in relation to aging and neurodegeneration. Yet, most of our knowledge of sleep neurophysiology in healthy individuals and patients has been limited by the capability of scalp EEG. EEG recordings, although extremely reliable, do not provide information with spatial specificity in the cortex nor do they provide information on the activity in subcortical areas, such as the medial temporal lobe and hippocampus, key brain areas involved in the study of cognitive decline due to dementia. fMRI provides superior spatial resolution of hemodynamics driven by neural activity, simultaneously in all brain areas, and provides a time resolution (seconds) relevant to sleep transitions (minutes) and their associated second scale events. However, attempts to obtain fMRI data during sleep have mostly been limited to light sleep in healthy young adults due to the difficulty of falling asleep and maintaining sleep in the MRI scanner environment where the acoustic noise is high, and participants are head-fixed in the coil. We will develop a novel platform to address these limitations and to enable simultaneous whole-night fMRI and polysomnographic recordings while the participants sleep naturally with minimal interruption. This platform will permit us to evaluate the coupling of fMRI brain activity and established polysomnographic recordings in a setup relevant for aged and clinical populations. Specifically, we will: (1) develop wearable high-density MRI head-cap arrays that are EEG compatible and allow the participants to adjust sleep posture while sleeping in the scanner environment; (2) adapt, and further develop silent fMRI using the looping-star sequence to eliminate acoustic noise while performing the scans; (3) develop an online real-time motion event classifier and scanner control for automatic sequence prescription for multiple head positions; (4) develop and integrate the analytical tools required to harmonize brain data recorded in multiple head positions; and (5) evaluate the platform in an aged population. Our proposed technology is highly innovative compared to the state of the art and addresses a significant need in the field of sleep studies. A success of the project will provide solution for simultaneous whole-night fMRI and polysomnographic recordings with quality comparable to that of clinical sleep labs outside MRI scanners. Our platform would open new diagnostic and research avenues, not possible today in patients and aged individuals.
Grant Summary
Sound Asleep: Technologies for uninterrupted whole night sleep recording in an MRI scanner is a NIBIB - National Institute of Biomedical Imaging and Bioengineering grant providing up to $611K for university, nonprofit, healthcare org. Applications are due 2030-03-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $611K
2030-03-31
- 1Confirm your organization is eligible for Sound Asleep: Technologies for uninterrupted whole night sleep recording in an MRI scanner from NIBIB - National Institute of Biomedical Imaging and Bioengineering, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIBIB - National Institute of Biomedical Imaging and Bioengineering before the deadline.
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Sound Asleep: Technologies for uninterrupted whole night sleep recording in an MRI scanner: Frequently Asked Questions
Who is eligible for the Sound Asleep: Technologies for uninterrupted whole night sleep recording in an MRI scanner?
Sound Asleep: Technologies for uninterrupted whole night sleep recording in an MRI scanner is offered by NIBIB - National Institute of Biomedical Imaging and Bioengineering and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Sound Asleep: Technologies for uninterrupted whole night sleep recording in an MRI scanner provide?
Sound Asleep: Technologies for uninterrupted whole night sleep recording in an MRI scanner provides up to $611K per award from NIBIB - National Institute of Biomedical Imaging and Bioengineering. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Sound Asleep: Technologies for uninterrupted whole night sleep recording in an MRI scanner deadline?
Applications for Sound Asleep: Technologies for uninterrupted whole night sleep recording in an MRI scanner are due 2030-03-31 (open). Because deadlines can change, verify the date with the funder, NIBIB - National Institute of Biomedical Imaging and Bioengineering, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Sound Asleep: Technologies for uninterrupted whole night sleep recording in an MRI scanner?
To apply for Sound Asleep: Technologies for uninterrupted whole night sleep recording in an MRI scanner, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIBIB - National Institute of Biomedical Imaging and Bioengineering.