Critical Crystal-Bacteria and Host Interactions Contributing to Kidney Stone Formation
NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
About This Grant
PROJECT SUMMARY This study aims to understand kidney stone formation by examining interactions between calcium oxalate (CaOx) crystals, bacteria, and host factors, with certain bacterial genes playing crucial roles. Kidney stones are increasingly common, especially among children, and current treatments have remained unchanged since the 1960s, focusing on preventing crystal formation rather than addressing the mechanisms that turn crystals into complex stones. Research has identified bacteria like Enterobacteriaceae in kidney stones, with experiments showing E. coli increases CaOx deposits in mice. The urinary microbiome differs in stone formers compared to healthy individuals, with some bacteria promoting stone formation and others offering protection. Genetic sequencing found two biofilm-related genes consistently present in stone-associated bacteria, suggesting potential targets for new treatments. Host immune proteins also contribute to stone formation, with stones containing layers of crystals and organic material. Preliminary data show certain proteins are more active when both E. coli and CaOx are present, forming layered stones. The hypothesis is that interactions between CaOx crystals, immune proteins, and bacteria facilitate stone formation. Aim 1 involves measuring how stone matrix proteins and bacteria interact to promote stone formation, while Aim 2 focuses on studying biofilm-related genes in stone-associated bacteria, using genomics and transcriptomics to identify and validate these genes. This research could lead to innovative treatments targeting specific bacterial genes and mechanisms to prevent and treat kidney stones.
Grant Summary
Critical Crystal-Bacteria and Host Interactions Contributing to Kidney Stone Formation is a NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases grant providing up to $729K for university, nonprofit, healthcare org. Applications are due 2030-12-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $729K
2030-12-31
- 1Confirm your organization is eligible for Critical Crystal-Bacteria and Host Interactions Contributing to Kidney Stone Formation from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases before the deadline.
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Critical Crystal-Bacteria and Host Interactions Contributing to Kidney Stone Formation: Frequently Asked Questions
Who is eligible for the Critical Crystal-Bacteria and Host Interactions Contributing to Kidney Stone Formation?
Critical Crystal-Bacteria and Host Interactions Contributing to Kidney Stone Formation is offered by NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Critical Crystal-Bacteria and Host Interactions Contributing to Kidney Stone Formation provide?
Critical Crystal-Bacteria and Host Interactions Contributing to Kidney Stone Formation provides up to $729K per award from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Critical Crystal-Bacteria and Host Interactions Contributing to Kidney Stone Formation deadline?
Applications for Critical Crystal-Bacteria and Host Interactions Contributing to Kidney Stone Formation are due 2030-12-31 (open). Because deadlines can change, verify the date with the funder, NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Critical Crystal-Bacteria and Host Interactions Contributing to Kidney Stone Formation?
To apply for Critical Crystal-Bacteria and Host Interactions Contributing to Kidney Stone Formation, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases.