Vitamin B5 regulation of inflammatory bowel disease
NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
About This Grant
ABSTRACT Pantothenic acid, also known as Vitamin B5 (VitB5), is a member of the vitamin B family found in diets and gut microbiota and is primarily absorbed by the intestines. VitB5 is a precursor for the biosynthesis of coenzyme A (CoA). As the major carrier of activated acyl groups within cells, CoA is critical in various core metabolic processes, including nutrient catabolism and lipid synthesis. VitB5 has been shown to regulate the functions of different cells and various diseases. Isolated VitB5 deficiency results in metabolic imbalance and gastrointestinal symptoms. A deficiency in VitB5 was recently reported in the blood and feces of IBD patients; accordingly, VitB5 administration enhanced intestinal barrier repair, suggesting a potential correlation between VitB5 reduction and IBD development. However, how VitB5 regulates IBD is still largely unknown. Our preliminary data showed a lower level of VitB5 in the serum of IBD patients and lower expression of pantothenate kinase (PANK), one of the enzymes that catabolize VB5 to CoA, in Foxp3+ Tregs in IBD patients, compared with healthy controls. This suggests a potential role of VitB5 in the regulation of IBD development through Tregs. We further showed that supplementation of VitB5 protects intestinal inflammation with higher levels of Foxp3+ Tregs in the intestines. This indicates a crucial role for VitB5 in regulating Treg and ongoing intestinal inflammation by promoting Foxp3+ Tregs. Thus, the central hypothesis of this project is that VitB5 protects the intestines from inflammation by promoting Treg suppressive function in the intestines. VitB5-SLC5A6 axis induces Foxp3+ Tregs through increased mitochondrial oxidation and epigenetic regulation, limiting intestinal inflammation progression in IBD. We will test our hypothesis in this application to determine (1) the impact of the VitB5-Slc5a6 axis in Tregs in the regulation of colitis.; (2) whether VitB5 promotes Treg function by enhancing Treg stemness; and (3) the mechanisms by which VitB5 promotes Treg stemness and the protection of intestinal inflammation.
Grant Summary
Vitamin B5 regulation of inflammatory bowel disease is a NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases grant providing up to $678K for university, nonprofit, healthcare org. Applications are due 2030-02-28 (open). Check eligibility and apply with FindGrants.
Not quite the right fit?
Search 9,000+ open grants, or get matches ranked for your organization — free.
Focus Areas
Eligibility
How to Apply
Up to $678K
2030-02-28
- 1Confirm your organization is eligible for Vitamin B5 regulation of inflammatory bowel disease from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases before the deadline.
Don't want to draft it yourself?
We'll draft the complete application against NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases's requirements, run a quality review, and email you a submission-ready PDF plus an editable Word doc within 5 business days. Most orders deliver in 24-48 hours. Flat $399, any grant size.
AI Requirement Analysis
Detailed requirements not yet analyzed
Have the NOFO? Paste it below for AI-powered requirement analysis.
Vitamin B5 regulation of inflammatory bowel disease: Frequently Asked Questions
Who is eligible for the Vitamin B5 regulation of inflammatory bowel disease?
Vitamin B5 regulation of inflammatory bowel disease is offered by NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Vitamin B5 regulation of inflammatory bowel disease provide?
Vitamin B5 regulation of inflammatory bowel disease provides up to $678K per award from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Vitamin B5 regulation of inflammatory bowel disease deadline?
Applications for Vitamin B5 regulation of inflammatory bowel disease are due 2030-02-28 (open). Because deadlines can change, verify the date with the funder, NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Vitamin B5 regulation of inflammatory bowel disease?
To apply for Vitamin B5 regulation of inflammatory bowel disease, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases.