Impact of Perinatal Western Diet on Offspring GLP1 Circuits
NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
About This Grant
Project Summary/Abstract In humans, rodents, and other mammals, the perinatal period of offspring development (i.e., gestational and lactational) is marked by significant neurodevelopment and plasticity. During this period, maternal nutrition strongly shapes the developmental assembly and later function of offspring neural circuits. Compelling clinical and pre-clinical evidence indicates that maternal consumption of "Western Diets" (WD) high in fat and sugar content promote offspring susceptibility to obesity, at least in part by increasing offspring preference for WD-type foods. Based on a strong foundation of published literature and pilot data obtained in our novel Gcg- Cre::tdTom reporter rat model, we propose that the deleterious effects of perinatal WD exposure in offspring occur, at least in part, as a consequence of developmental plasticity and persistently altered function of central glucagon-like 1 (GLP1) signaling pathways. We specifically hypothesize that perinatal maternal WD alters the structure and function of GLP1 axonal projections in offspring, thereby reducing endogenous GLP1R signaling in reward- related brain regions that control palatable food intake. To test predictions arising from this overarching hypothesis, we will (1) document the nature and persistence of perinatal WD- induced plasticity in central GLP1 signaling pathways in male and female offspring, (2) examine how alterations in the structure and function of central GLP1 signaling pathways are associated with behavioral and physiological outcomes, and (3) investigate whether adolescent-onset treatment with the brain-penetrant GLP1R analogue semaglutide (SEMA) abrogates the effects of perinatal WD on offspring behavior, physiology, and endogenous GLP1R signaling. By elucidating for the first time how perinatal WD exposure impacts the structure and function of the central GLP1 system, results from this project will provide new insights regarding how the early nutritional environment modifies food reward-driven behaviors and lifespan metabolic health. If our data support this hypothesis, the results will have implications for developing strategies to combat long-term health adversities associated with early life exposure to WD.
Grant Summary
Impact of Perinatal Western Diet on Offspring GLP1 Circuits is a NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases grant providing up to $593K for university, nonprofit, healthcare org. Applications are due 2031-01-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $593K
2031-01-31
- 1Confirm your organization is eligible for Impact of Perinatal Western Diet on Offspring GLP1 Circuits from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases before the deadline.
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Impact of Perinatal Western Diet on Offspring GLP1 Circuits: Frequently Asked Questions
Who is eligible for the Impact of Perinatal Western Diet on Offspring GLP1 Circuits?
Impact of Perinatal Western Diet on Offspring GLP1 Circuits is offered by NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Impact of Perinatal Western Diet on Offspring GLP1 Circuits provide?
Impact of Perinatal Western Diet on Offspring GLP1 Circuits provides up to $593K per award from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Impact of Perinatal Western Diet on Offspring GLP1 Circuits deadline?
Applications for Impact of Perinatal Western Diet on Offspring GLP1 Circuits are due 2031-01-31 (open). Because deadlines can change, verify the date with the funder, NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Impact of Perinatal Western Diet on Offspring GLP1 Circuits?
To apply for Impact of Perinatal Western Diet on Offspring GLP1 Circuits, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases.