A Novel Regulator of Erythrocyte Hydration and Red Blood Cell Traits
NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
About This Grant
Project Description/Summary Reticulocyte maturation, the final stage of erythropoiesis, is critical for blood formation. Despite its importance in disease pathology, including inherited and acquired disorders of the erythrocyte, it is an understudied area. A major aspect of reticulocyte maturation is gradual loss of salt and water over time. Maintenance of water and solute homeostasis is critical to survival of both the reticulocyte and the mature erythrocyte. We have identified a novel regulator of erythrocyte hydration in erythropoiesis. In conjunction with the kinase WNK1, this TGF beta- stimulated clone (TSC) 22 family member controls potassium-chloride cotransport in reticulocytes and mature erythrocytes, shrinking reticulocytes to their normal volume in mature red blood cells. The goal of specific aim one is the identification of interacting proteins and characterization of regulator-WNK1 interactions and their influence on cellular hydration. The goal of specific aim two is elucidation of the influence of genetic variants on erythrocyte phenotype in humans and murine in vivo models of perturbed erythrocyte hydration. The overall goal of this proposal, which combines state of the art cellular, molecular, and genetic technologies in an innovative, multidisciplinary manner, is to characterize the structure and function of regulatory complexes in erythroid cells to better understand the mechanisms regulating erythrocyte volume homeostasis. These studies will extend our knowledge of normal erythropoiesis, particularly reticulocyte maturation. They will also provide a better understanding of the contribution of regulatory proteins to erythroid cell traits and its contribution to erythroid cell phenotype in inherited and acquired disorders of the erythrocyte.
Grant Summary
A Novel Regulator of Erythrocyte Hydration and Red Blood Cell Traits is a NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases grant providing up to $518K for university, nonprofit, healthcare org. Applications are due 2030-02-28 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $518K
2030-02-28
- 1Confirm your organization is eligible for A Novel Regulator of Erythrocyte Hydration and Red Blood Cell Traits from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases before the deadline.
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A Novel Regulator of Erythrocyte Hydration and Red Blood Cell Traits: Frequently Asked Questions
Who is eligible for the A Novel Regulator of Erythrocyte Hydration and Red Blood Cell Traits?
A Novel Regulator of Erythrocyte Hydration and Red Blood Cell Traits is offered by NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the A Novel Regulator of Erythrocyte Hydration and Red Blood Cell Traits provide?
A Novel Regulator of Erythrocyte Hydration and Red Blood Cell Traits provides up to $518K per award from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the A Novel Regulator of Erythrocyte Hydration and Red Blood Cell Traits deadline?
Applications for A Novel Regulator of Erythrocyte Hydration and Red Blood Cell Traits are due 2030-02-28 (open). Because deadlines can change, verify the date with the funder, NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the A Novel Regulator of Erythrocyte Hydration and Red Blood Cell Traits?
To apply for A Novel Regulator of Erythrocyte Hydration and Red Blood Cell Traits, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases.