Neural Circuits in Preoptic Hypothalamus Regulating Energy Expenditure and Metabolism
NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
About This Grant
PROJECT ABSTRACT Obesity-associated metabolic diseases have roots in the maladaptation of hypothalamic circuits. Compared to neural circuits regulating energy intake, mechanisms regulating energy expenditure have been less studied and poorly understood; however, they remain appealing therapeutic targets. This is particularly true for increasing thermogenic expenditure (non-shivering thermogenesis), which may carry additional benefits from increased brown adipose tissue (BAT) activity. Further, white adipose tissue which as a central role in obesity induced disorders can undergo remodeling to become more like BAT becoming beige adipose tissue with increase metabolic activity. The long-term goal of this project is to identify and elucidate the functioning of hypothalamic neural circuits that regulate energy balance and metabolism, thereby addressing these growing disease burdens. Converging lines of study led to identification of a subpopulation of neurons in the preoptic area of the hypothalamus (POA) that express KOR (POAKOR+). Evidence indicates the kappa opioid system is important for the regulation of energy balance and metabolism, but the putative roles of KOR-expressing neurons are not yet known. Preliminary data indicate that POAKOR+ neurons regulate energy expenditure and metabolic pathways. The central hypotheses of this proposal are that POAKOR+ neurons are: (Aim 1) recruited following by circadian timing and inhibited by feeding; (Aim 2) are key regulators of energy expenditure; and (Aim 3) can be targeted to drive negative energy balance, cause weight loss due to decreased adipose tissue, improve markers of metabolic health, and remodel white adipose tissue. To test these hypotheses, a range of methods, including fiber photometry, indirect calorimetry, metabolic profiling, home cage monitoring, thermal imaging, and MS metabolomics will be utilized. Results from the proposed studies are expected to inform our understanding of hypothalamic circuits regulating energy expenditure and metabolic activity, by demonstrating that POAKOR+ neurons are previously unappreciated important regulators of energy expenditure and metabolism. Supporting the translational relevance of POAKOR+ neurons, data from the Allen database show KOR expression is enriched in the human preoptic hypothalamus. The studies will determine if POAKOR+ neurons are potential therapeutic targets to modulate energy balance (weight loss) and metabolic dysfunction.
Grant Summary
Neural Circuits in Preoptic Hypothalamus Regulating Energy Expenditure and Metabolism is a NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases grant providing up to $720K for university, nonprofit, healthcare org. Applications are due 2031-01-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $720K
2031-01-31
- 1Confirm your organization is eligible for Neural Circuits in Preoptic Hypothalamus Regulating Energy Expenditure and Metabolism from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases before the deadline.
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Neural Circuits in Preoptic Hypothalamus Regulating Energy Expenditure and Metabolism: Frequently Asked Questions
Who is eligible for the Neural Circuits in Preoptic Hypothalamus Regulating Energy Expenditure and Metabolism?
Neural Circuits in Preoptic Hypothalamus Regulating Energy Expenditure and Metabolism is offered by NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Neural Circuits in Preoptic Hypothalamus Regulating Energy Expenditure and Metabolism provide?
Neural Circuits in Preoptic Hypothalamus Regulating Energy Expenditure and Metabolism provides up to $720K per award from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Neural Circuits in Preoptic Hypothalamus Regulating Energy Expenditure and Metabolism deadline?
Applications for Neural Circuits in Preoptic Hypothalamus Regulating Energy Expenditure and Metabolism are due 2031-01-31 (open). Because deadlines can change, verify the date with the funder, NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Neural Circuits in Preoptic Hypothalamus Regulating Energy Expenditure and Metabolism?
To apply for Neural Circuits in Preoptic Hypothalamus Regulating Energy Expenditure and Metabolism, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases.