Impacts of HIV and nicotine on T cell neuroinvasion and HIV CNS reservoir seeding
NIDA - National Institute on Drug Abuse
About This Grant
HIV infection and nicotine addiction are significant global health issues, particularly among young adults, with increasing co-occurrence. Despite successful antiretroviral therapy (ART), 30–60% of people living with HIV (PLWH) develop HIV-associated neurocognitive disorders (HAND). Nicotine negatively impacts HIV⁺ individuals, potentially contributing to disease progression by facilitating neuroinvasion through CD4⁺ T cells that cross the blood-brain barrier (BBB). These cells, once in the central nervous system (CNS), release neurotoxic particles and inflammatory cytokines, leading to synaptic damage. Chronic nicotine activates nicotinic acetylcholine receptors (nAChRs) on T cells, enhancing their proliferation and cytokine release. Our hypothesis is that chronic nicotine enhances HIV⁺ CD4⁺ T cell neuroinvasion through convergent chemotactic signaling involving HIV gp120 and nicotine receptor activation. We will test this hypothesis through three aims. Aim 1 is to investigate how HIV infection promotes chemotaxic signaling in CD4⁺ T cell neuroinvasion, utilizing an in vitro BBB transmigration assay and measuring the phosphorylation of cytoskeletal regulators. Aim 2 is to assess chronic nicotine's effects on HIV⁺ CD4⁺ T cell proliferation and pro-inflammatory responses, focusing on nAChR expression and activation of chemotactic signaling pathways. Aim 3 is to evaluate the effects of chronic nicotine and HIV infection on CD4⁺ T cell behavior in an HIV humanized mouse model, monitoring inflammatory cytokines, viral reservoirs, and neuroinvasion in brain regions susceptible to T cell infiltration. This study is proposed by a strong team of co-PIs with complementary expertise in HIV signaling, nicotine research, T cell immunology, and drug abuse animal models, ensuring a comprehensive approach to understanding the interplay between HIV and nicotine addiction in neuroinvasion.
Grant Summary
Impacts of HIV and nicotine on T cell neuroinvasion and HIV CNS reservoir seeding is a NIDA - National Institute on Drug Abuse grant providing up to $710K for university, nonprofit, healthcare org. Applications are due 2031-02-28 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $710K
2031-02-28
- 1Confirm your organization is eligible for Impacts of HIV and nicotine on T cell neuroinvasion and HIV CNS reservoir seeding from NIDA - National Institute on Drug Abuse, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDA - National Institute on Drug Abuse before the deadline.
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Impacts of HIV and nicotine on T cell neuroinvasion and HIV CNS reservoir seeding: Frequently Asked Questions
Who is eligible for the Impacts of HIV and nicotine on T cell neuroinvasion and HIV CNS reservoir seeding?
Impacts of HIV and nicotine on T cell neuroinvasion and HIV CNS reservoir seeding is offered by NIDA - National Institute on Drug Abuse and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Impacts of HIV and nicotine on T cell neuroinvasion and HIV CNS reservoir seeding provide?
Impacts of HIV and nicotine on T cell neuroinvasion and HIV CNS reservoir seeding provides up to $710K per award from NIDA - National Institute on Drug Abuse. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Impacts of HIV and nicotine on T cell neuroinvasion and HIV CNS reservoir seeding deadline?
Applications for Impacts of HIV and nicotine on T cell neuroinvasion and HIV CNS reservoir seeding are due 2031-02-28 (open). Because deadlines can change, verify the date with the funder, NIDA - National Institute on Drug Abuse, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Impacts of HIV and nicotine on T cell neuroinvasion and HIV CNS reservoir seeding?
To apply for Impacts of HIV and nicotine on T cell neuroinvasion and HIV CNS reservoir seeding, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDA - National Institute on Drug Abuse.