The impact of substance use on the role of T cells in HIV CNS reservoir seeding, persistence, and neuropathogenesis
About This Grant
Cannabis use is high in PLWH, ~25-35% of PLWH report cannabis consumption. Cannabinoids have been shown to have anti-inflammatory properties in humans and animal models. Heavy cannabis use in PLWH on ART is associated with decreased levels of activated T cells in peripheral blood. The two main cannabinoids present in cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC, the psychoactive component of cannabis, is a partial agonist for cannabinoid receptors CB1 and CB2. CB1 is primarily expressed in the brain while CB2 is reportedly expressed in immune cells, including CD4+ T cells. THC exposure modulates human CD4+ T cell gene expression and in animal models skews immune responses towards a Th2 phenotype and increases CD4+ T cell production of anti-inflammatory and immunosuppressive cytokines. CBD has anti-inflammatory and antioxidant effects without the psychoactive properties of THC. CBD exposure has been shown to suppress T cell proliferation, T cell production of IL-2 and IFN-γ production in T cells. Cannabinoid treatment has also been shown to suppress neuroinflammation in animal models of Alzheimer’s disease and multiple sclerosis. Importantly, in non-human primates (NHP) cannabinoid treatment reduced SIV-induced neuroinflammation. Based on these immunomodulatory properties of cannabinoids, we hypothesize that cannabinoids impact HIV infection and persistence in the CNS. Currently, it is not known how cannabis use impacts the phenotype of CD4+ T cells in the brain and their relative abundance and distribution. Therefore, as part of this project we will evaluate the effect of cannabinoids on the natural homeostasis of human T cells in the brain. We will then assess the impact of cannabinoids on the seeding of HIV infection in CD4+ T cells in the brain, the establishment of HIV latency in brain CD4+ T cells, and the efficacy of latency reversal agents to induce HIV expression in CD4+ T cells in the brain under ART-suppression.
Grant Summary
The impact of substance use on the role of T cells in HIV CNS reservoir seeding, persistence, and neuropathogenesis is a NIDA - National Institute on Drug Abuse grant providing up to $883K for university, nonprofit, healthcare org. Applications are due 2031-01-31 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $883K
2031-01-31
- 1Confirm your organization is eligible for The impact of substance use on the role of T cells in HIV CNS reservoir seeding, persistence, and neuropathogenesis from NIDA - National Institute on Drug Abuse, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDA - National Institute on Drug Abuse before the deadline.
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The impact of substance use on the role of T cells in HIV CNS reservoir seeding, persistence, and neuropathogenesis: Frequently Asked Questions
Who is eligible for the The impact of substance use on the role of T cells in HIV CNS reservoir seeding, persistence, and neuropathogenesis?
The impact of substance use on the role of T cells in HIV CNS reservoir seeding, persistence, and neuropathogenesis is offered by NIDA - National Institute on Drug Abuse and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the The impact of substance use on the role of T cells in HIV CNS reservoir seeding, persistence, and neuropathogenesis provide?
The impact of substance use on the role of T cells in HIV CNS reservoir seeding, persistence, and neuropathogenesis provides up to $883K per award from NIDA - National Institute on Drug Abuse. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the The impact of substance use on the role of T cells in HIV CNS reservoir seeding, persistence, and neuropathogenesis deadline?
Applications for The impact of substance use on the role of T cells in HIV CNS reservoir seeding, persistence, and neuropathogenesis are due 2031-01-31 (open). Because deadlines can change, verify the date with the funder, NIDA - National Institute on Drug Abuse, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the The impact of substance use on the role of T cells in HIV CNS reservoir seeding, persistence, and neuropathogenesis?
To apply for The impact of substance use on the role of T cells in HIV CNS reservoir seeding, persistence, and neuropathogenesis, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDA - National Institute on Drug Abuse.