Identifying spatial tumor microenvironment signatures for risk stratification in primary melanoma
NCI - National Cancer Institute
About This Grant
ABSTRACT The importance of tumor microenvironment (TME) in regulating cancer progression and influencing therapeutic outcome is widely appreciated. Recent developments in multiplexed tissue imaging technology offer powerful platforms for dissecting the spatial biology of TME by enabling the simultaneous detection of multiple markers of interest on a single tissue slide. In this study, we will perform whole-slide multiplex immunofluorescence (mIF) tissue imaging analysis of 450 InterMEL Stage II/III primary invasive melanomas focusing on markers staining the immune cells and tumor vasculature. InterMEL is a case-control study that retrospectively enrolled pathological AJCC8 stage IIA-IIID cutaneous primary melanoma patients from 15 hospitals or treatment centers in the USA, Australia, and Spain. Cases were patients who had died of melanoma within 5 years of diagnosis; controls were patients who had survived for at least 5 years without evidence of melanoma recurrence. The outcome of the study will advance the field in several ways including a large mIF image data repository generated in primary melanoma; innovative computational methods and tools for spatial immuno-phenotyping and for identifying spatial TME signatures to distinguish aggressive versus indolent disease.
Grant Summary
Identifying spatial tumor microenvironment signatures for risk stratification in primary melanoma is a NCI - National Cancer Institute grant providing up to $693K for university, nonprofit, healthcare org. Applications are due 2031-04-30 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $693K
2031-04-30
- 1Confirm your organization is eligible for Identifying spatial tumor microenvironment signatures for risk stratification in primary melanoma from NCI - National Cancer Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NCI - National Cancer Institute before the deadline.
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Identifying spatial tumor microenvironment signatures for risk stratification in primary melanoma: Frequently Asked Questions
Who is eligible for the Identifying spatial tumor microenvironment signatures for risk stratification in primary melanoma?
Identifying spatial tumor microenvironment signatures for risk stratification in primary melanoma is offered by NCI - National Cancer Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Identifying spatial tumor microenvironment signatures for risk stratification in primary melanoma provide?
Identifying spatial tumor microenvironment signatures for risk stratification in primary melanoma provides up to $693K per award from NCI - National Cancer Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Identifying spatial tumor microenvironment signatures for risk stratification in primary melanoma deadline?
Applications for Identifying spatial tumor microenvironment signatures for risk stratification in primary melanoma are due 2031-04-30 (open). Because deadlines can change, verify the date with the funder, NCI - National Cancer Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Identifying spatial tumor microenvironment signatures for risk stratification in primary melanoma?
To apply for Identifying spatial tumor microenvironment signatures for risk stratification in primary melanoma, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NCI - National Cancer Institute.