Molecular mechanisms of telomere function in muscle cells
NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases
About This Grant
Project Summary/Abstract Tissue restoration is essential to maintain skeletal muscles after injury, due to overuse, aging or disease. Repeated cycles of muscle damage and repair are associated with muscle stem cell (MuSC) dysfunction and impaired myogenesis. Telomeres protect and stability and telomeric proteins do not only the end of our chromosomes from deterioration but are main components of the stem cell progenitor cells `ignition' mechanism, which maintain tissue homeostasis and genome by repairing damage throughout life .Although the telomere protective machinery has been primarily established during carcinogenesis and aging; its importance during regeneration and particularly in muscle injuries, a tissue known for its high regenerative capacity and low propensity for carcinogenesis, is not well understood. We previously demonstrated that telomere attrition is a distinct feature of dystrophic MuSCs in both mice and patients, even at very young ages. More recently, we discovered that TRF2, a key telomere-capping protein, is dynamically regulated in skeletal muscles and has distinct functions, independent of its conventional telomeric role. We also developed genetic tools to define how this protein operates in uninjured, injured, and diseased skeletal muscles. The studies proposed here will determine the extent of previously unknown extra-telomeric functions of TRF2 in muscle stem cells (Aim 1), they will define its new role in regenerating myofibers upon acute and chronic injuries and will uncover new interacting proteins during this process (Aim 2). We expect that this project will fundamentally advance our understanding of the molecular mechanisms by which TRF2 maintains stem cell identity versus how it regulates reparative myogenesis and could effectively guide ways of promoting regeneration and function in healthy and diseased conditions.
Grant Summary
Molecular mechanisms of telomere function in muscle cells is a NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases grant providing up to $546K for university, nonprofit, healthcare org. Applications are due 2031-03-31 (open). Check eligibility and apply with FindGrants.
Not quite the right fit?
Search 9,000+ open grants, or get matches ranked for your organization — free.
Focus Areas
Eligibility
How to Apply
Up to $546K
2031-03-31
- 1Confirm your organization is eligible for Molecular mechanisms of telomere function in muscle cells from NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases before the deadline.
Don't want to draft it yourself?
We'll draft the complete application against NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases's requirements, run a quality review, and email you a submission-ready PDF plus an editable Word doc within 5 business days. Most orders deliver in 24-48 hours. Flat $399, any grant size.
AI Requirement Analysis
Detailed requirements not yet analyzed
Have the NOFO? Paste it below for AI-powered requirement analysis.
Molecular mechanisms of telomere function in muscle cells: Frequently Asked Questions
Who is eligible for the Molecular mechanisms of telomere function in muscle cells?
Molecular mechanisms of telomere function in muscle cells is offered by NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Molecular mechanisms of telomere function in muscle cells provide?
Molecular mechanisms of telomere function in muscle cells provides up to $546K per award from NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Molecular mechanisms of telomere function in muscle cells deadline?
Applications for Molecular mechanisms of telomere function in muscle cells are due 2031-03-31 (open). Because deadlines can change, verify the date with the funder, NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Molecular mechanisms of telomere function in muscle cells?
To apply for Molecular mechanisms of telomere function in muscle cells, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases.