Combination of CCR5 blockade with broadly neutralizing antibodies to clear the HIV viral reservoir
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
PROJECT SUMMARY With the most people ever in history currently living with HIV, stopping the HIV epidemic remains imperative. Combination antiretroviral therapy (ART) limits viral replication, but is not curative. Thus, there is an urgent need to design a functional cure via elimination of the viral reservoir. We recently found that the combination of antiretroviral therapy, broadly neutralizing antibodies, and CCR5 blockade were able to completely clear establishment of infection in newborn macaques when delivered by day three post-infection. However, it remains unclear how far post-infection this treatment window extends in newborns and if this treatment is also effective in adults. In specific aim 1, we will systematically identify the window of opportunity for this novel triple therapy treatment to clear the latent reservoir by delaying treatment multiple days. In specific aim 2, we will determine if this remarkable clearance of reservoir establishment via triple therapy is also effective in adults infected via sexual transmission. Because all three components of this triple therapy are currently being tested individually in humans, successful completion of the aims here will set the stage for clinical trials to for HIV cure.
Grant Summary
Combination of CCR5 blockade with broadly neutralizing antibodies to clear the HIV viral reservoir is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $877K for university, nonprofit, healthcare org. Applications are due 2031-05-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $877K
2031-05-31
- 1Confirm your organization is eligible for Combination of CCR5 blockade with broadly neutralizing antibodies to clear the HIV viral reservoir from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Combination of CCR5 blockade with broadly neutralizing antibodies to clear the HIV viral reservoir: Frequently Asked Questions
Who is eligible for the Combination of CCR5 blockade with broadly neutralizing antibodies to clear the HIV viral reservoir?
Combination of CCR5 blockade with broadly neutralizing antibodies to clear the HIV viral reservoir is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Combination of CCR5 blockade with broadly neutralizing antibodies to clear the HIV viral reservoir provide?
Combination of CCR5 blockade with broadly neutralizing antibodies to clear the HIV viral reservoir provides up to $877K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Combination of CCR5 blockade with broadly neutralizing antibodies to clear the HIV viral reservoir deadline?
Applications for Combination of CCR5 blockade with broadly neutralizing antibodies to clear the HIV viral reservoir are due 2031-05-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Combination of CCR5 blockade with broadly neutralizing antibodies to clear the HIV viral reservoir?
To apply for Combination of CCR5 blockade with broadly neutralizing antibodies to clear the HIV viral reservoir, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.