Trained immunity signatures of reduced vaccine responses in older adults
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
PROJECT SUMMARY Aging leads to widespread changes in the immune system, including increased inflammation, diminished vaccine responsiveness, and greater susceptibility to infection and chronic disease. However, older adults vary significantly in their immune trajectories—some maintain robust function, while others experience immune decline. The biological mechanisms driving this heterogeneity remain poorly understood, particularly the role of upstream hematopoietic stem and progenitor cells (HSPCs), which continually regenerate the immune system throughout life. This project tests the central hypothesis that epigenetic remodeling of HSPCs contributes to immune-related hallmarks of aging and variability in these phenotypes, shaping both inflammatory set points and immune responsiveness in older adults. To address this, we leverage a well-characterized, longitudinal cohort of 62 older adults, each of whom received a different influenza vaccine over three consecutive seasons. Using our novel PBMC-PIE platform—developed to enrich and profile circulating HSPCs from cryopreserved PBMCs at single-cell resolution—we can interrogate progenitor cell states and their progeny without requiring bone marrow biopsies. This enables unprecedented, longitudinal insight into how human HSPCs are reprogrammed with age and vaccination. In Aim 1, we will identify molecular and epigenomic features in HSPCs and innate immune cells that distinguish strong from poor vaccine responders. In Aim 2, we will determine how different influenza vaccine platforms (high-dose, adjuvanted, recombinant) shape the chromatin landscape and lineage bias of HSPCs and their progeny over time. In Aim 3, we will test whether maladaptive “aged” HSPC states can be rejuvenated in vitro using candidate immunomodulatory factors identified in Aims 1–2. By linking blood-based epigenetic signatures to real-world immune outcomes, this work will reveal fundamental mechanisms of immune aging, identify biomarkers of immune resilience, and inform the development of targeted strategies to restore immune function in older adults.
Grant Summary
Trained immunity signatures of reduced vaccine responses in older adults is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $933K for university, nonprofit, healthcare org. Applications are due 2031-05-31 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $933K
2031-05-31
- 1Confirm your organization is eligible for Trained immunity signatures of reduced vaccine responses in older adults from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Trained immunity signatures of reduced vaccine responses in older adults: Frequently Asked Questions
Who is eligible for the Trained immunity signatures of reduced vaccine responses in older adults?
Trained immunity signatures of reduced vaccine responses in older adults is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Trained immunity signatures of reduced vaccine responses in older adults provide?
Trained immunity signatures of reduced vaccine responses in older adults provides up to $933K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Trained immunity signatures of reduced vaccine responses in older adults deadline?
Applications for Trained immunity signatures of reduced vaccine responses in older adults are due 2031-05-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Trained immunity signatures of reduced vaccine responses in older adults?
To apply for Trained immunity signatures of reduced vaccine responses in older adults, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.