Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
PROJECT SUMMARY Invasive infections related to the saprophytic mold Aspergillus fumigatus are on the rise, and drug resistance often exacerbates the problem. The mechanisms of fungal adaptation to the azole drugs are not clear. Recently, it has been shown that A. fumigatus can form persistent colonies in response to azole drugs. Long non-coding (lnc)RNAs have been associated with stress adaptation that may eventually lead to resistance. This research team has identified a lncRNA, afu-182, that acts as a negative regulator of azole tolerance. This project will now use innovative approaches to identify the role(s) of afu-182 and delineate the azole response network in A. fumigatus. Aim 1 will characterize the roles of the RTM family of proteins, a class of protein that is involved in ameliorating xenobiotic stress, and define their regulation by afu-182. Aim 2 will study the structure-function relationship of afu-182 to understand the mechanistic basis of afu-182 action. Aim 3 will study a closely related homothallic fungus, Aspergillus nidulans, with a short, defined sexual cycle in an unbiased forward-genetics approach to identify novel factors in azole response. Using a new fundamental paradigm of study, this project will determine the novel mechanisms of azole response in Aspergilli, which will eventually reveal new strategies to combat the rise of azole drug resistance.
Grant Summary
Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $418K for university, nonprofit, healthcare org. Applications are due 2031-03-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $418K
2031-03-31
- 1Confirm your organization is eligible for Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance: Frequently Asked Questions
Who is eligible for the Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance?
Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance provide?
Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance provides up to $418K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance deadline?
Applications for Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance are due 2031-03-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance?
To apply for Long-noncoding RNAafu-182- A novel regulator of fungal triazole tolerance, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.