Lipidomic discovery of physiological CD1 antigens and blockers for human T cells
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
Modified Project Summary/Abstract Section T cells control immune response during vaccination, autoimmunity and infection based on their recognition of antigens. This R01 resubmission proposal studies lipid antigens for T cells by taking advantage of a sensitive lipidomics platform that can comprehensively detect lipids bound to CD1 antigen presenting molecules. By detecting hundreds of lipids bound to human CD1a, CD1b, CD1c and CD1d, we will determine the general patterns of lipid capture by cellular CD1 proteins. By separating CD1 proteins that do and do not bind to T cell receptors, lipidome-scale experiments will identify chemical patterns in natural lipids that lead to activation and blockade of T cell response. Based on a prior program that identified CD1a ligands that block T cell response in vivo, we will determine the structures of CD1b, CD1c and CD1d ligands that are inhibitors for T cells. Finally, optimized blockers will be tested ex vivo using polyclonal human T cells and CD1 tetramers, with an emphasis on CD1a and CD1c blockers. Overall, we seek to develop anti-inflammatory therapies that can act through specific blockade of human T cells. Unlike the MHC antigen presenting molecules, CD1 proteins are non-polymorphic, meaning that once the CD1-lipid binding patterns are described, they will apply to nearly all humans.
Grant Summary
Lipidomic discovery of physiological CD1 antigens and blockers for human T cells is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $893K for university, nonprofit, healthcare org. Applications are due 2031-03-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $893K
2031-03-31
- 1Confirm your organization is eligible for Lipidomic discovery of physiological CD1 antigens and blockers for human T cells from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Lipidomic discovery of physiological CD1 antigens and blockers for human T cells: Frequently Asked Questions
Who is eligible for the Lipidomic discovery of physiological CD1 antigens and blockers for human T cells?
Lipidomic discovery of physiological CD1 antigens and blockers for human T cells is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Lipidomic discovery of physiological CD1 antigens and blockers for human T cells provide?
Lipidomic discovery of physiological CD1 antigens and blockers for human T cells provides up to $893K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Lipidomic discovery of physiological CD1 antigens and blockers for human T cells deadline?
Applications for Lipidomic discovery of physiological CD1 antigens and blockers for human T cells are due 2031-03-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Lipidomic discovery of physiological CD1 antigens and blockers for human T cells?
To apply for Lipidomic discovery of physiological CD1 antigens and blockers for human T cells, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.