Host lipid acquisition and maintenance of the Chlamydia replicative niche
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
SUMMARY Chlamydia trachomatis is the leading cause of sexually transmitted infections of bacterial origin. No vaccine is available. Infections are often asymptomatic, leading to long-term damage of the reproductive organs and deleterious effects on women reproductive health ranging from pelvic inflammatory disease to infertility. The identification and characterization of essential Chlamydia specific factors is paramount to help in the design of effective therapeutics and/or vaccine, but the lag in Chlamydia genetics and the obligate intracellular nature of the pathogens have complicated this process. Here, we identified the first essential Chlamydia inclusion membrane protein. Based on the phenotypes of the corresponding mutant and the link to sphingolipid acquisition, we propose to test the hypothesis that a single Inc protein plays an essential role in preserving the integrity of the replicative niche by mediating the non-vesicular trafficking of sphingolipid to the inclusion and thereby contributes to pathogenesis. Our multidisciplinary approach will provide answers to fundamental biological questions regarding the role of host lipid acquisition in preserving the integrity of the Chlamydia replicative niche and cause disease. Additionally, our studies will reveal how a single Inc protein contribute to this process, thereby reinforcing the potential of these Chlamydia specific proteins as targets to design effective therapeutics and/or vaccines.
Grant Summary
Host lipid acquisition and maintenance of the Chlamydia replicative niche is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $718K for university, nonprofit, healthcare org. Applications are due 2031-01-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $718K
2031-01-31
- 1Confirm your organization is eligible for Host lipid acquisition and maintenance of the Chlamydia replicative niche from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Host lipid acquisition and maintenance of the Chlamydia replicative niche: Frequently Asked Questions
Who is eligible for the Host lipid acquisition and maintenance of the Chlamydia replicative niche?
Host lipid acquisition and maintenance of the Chlamydia replicative niche is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Host lipid acquisition and maintenance of the Chlamydia replicative niche provide?
Host lipid acquisition and maintenance of the Chlamydia replicative niche provides up to $718K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Host lipid acquisition and maintenance of the Chlamydia replicative niche deadline?
Applications for Host lipid acquisition and maintenance of the Chlamydia replicative niche are due 2031-01-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Host lipid acquisition and maintenance of the Chlamydia replicative niche?
To apply for Host lipid acquisition and maintenance of the Chlamydia replicative niche, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.