Marrow adipocytes modify the neural regulation of bone
NIA - National Institute on Aging
About This Grant
ABSTRACT Bone marrow adipose tissue (BMAT) is a heterogenous and understudied adipose depot that fills approximately 70% of the adult human skeleton. Despite its abundance, the regulatory mechanisms and functional roles of bone marrow adipocytes (BMAds) remain poorly understood, particularly in the context of constitutive BMAd catabolism and its implications for skeletal health. The overall goal of this project is to define the neuro-adipose-bone crosstalk within the cBMAd-containing skeletal niche to promote the design and implementation of novel strategies to support bone health. Our central hypothesis is that activation of adaptive cBMAd lipolysis drives transcriptional remodeling to support anabolic cBMAd-osteoblast coupling in states of high sympathetic tone and neurosystemic stress, providing localized protection against age- and disease- associated bone loss. To test this hypothesis, we propose two specific aims. Aim 1 will define the mechanisms of cBMAd-mediated anabolism and bone protection and explore conservation in aged/post-menopausal states while creating new bioinformatic-based digital twin models that will inform personalized strategies to preserve skeletal integrity by computationally modeling cBMAd responses to physiological and pathological stress. Aim 2 will isolate the fate of catabolized cBMAds, quantify the changes in bone and muscle that occur after complete cBMAd loss while clarifying potential for recovery, and determine the lifespan and differentiation potential of cBMAds in vivo. This moves beyond established pathways to define mechanisms underlying the local role of cBMAds in the mitigation of the bone suppressive effects of high sympathetic tone. In addition to informing therapies to support healthy skeletal aging, this research has important implications for prevention of bone loss and fracture in diverse forms of wasting and cachexia and will support the development of new treatments to increase and preserve bone mass in settings of neurosystemic stress.
Grant Summary
Marrow adipocytes modify the neural regulation of bone is a NIA - National Institute on Aging grant providing up to $518K for university, nonprofit, healthcare org. Applications are due 2031-01-31 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $518K
2031-01-31
- 1Confirm your organization is eligible for Marrow adipocytes modify the neural regulation of bone from NIA - National Institute on Aging, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIA - National Institute on Aging before the deadline.
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Marrow adipocytes modify the neural regulation of bone: Frequently Asked Questions
Who is eligible for the Marrow adipocytes modify the neural regulation of bone?
Marrow adipocytes modify the neural regulation of bone is offered by NIA - National Institute on Aging and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Marrow adipocytes modify the neural regulation of bone provide?
Marrow adipocytes modify the neural regulation of bone provides up to $518K per award from NIA - National Institute on Aging. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Marrow adipocytes modify the neural regulation of bone deadline?
Applications for Marrow adipocytes modify the neural regulation of bone are due 2031-01-31 (open). Because deadlines can change, verify the date with the funder, NIA - National Institute on Aging, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Marrow adipocytes modify the neural regulation of bone?
To apply for Marrow adipocytes modify the neural regulation of bone, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIA - National Institute on Aging.